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参芪降糖颗粒辅助治疗2型糖尿病性膝关节炎的临床观察
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| 篇名： | 参芪降糖颗粒辅助治疗2型糖尿病性膝关节炎的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察参芪降糖颗粒辅助治疗2型糖尿病性膝关节炎的疗效和安全性。方法：62例2型糖尿病性膝关节炎患者随机分为对照组（31例）和观察组（31例）。对照组患者均给予降糖、针对关节炎的基础治疗，包括饮食控制、运动疗法及健康教育，同时口服盐酸二甲双胍片0.25 g，每日3次，餐中服用+阿卡波糖片50 mg，每日3次，餐中嚼服；关节炎疼痛患者服用阿司匹林肠溶片100 mg，每日1次，饭后口服（不可嚼碎或掰开服用）。观察组患者在对照组治疗的基础上给予参芪降糖颗粒3 g，每日3次，餐前半小时用50 ml温水冲服。两组疗程均为6个月。观察两组患者的临床疗效，治疗前后的空腹血糖（FPG）、餐后2 h血糖（2 h PG）、糖化血红蛋白（HbA1c）、白细胞介素（IL）-1β、IL-6及不良反应发生情况。结果：观察组患者总有效率显著高于对照组，差异有统计学意义（P＜0.05）。治疗前，两组患者FPG、2 h PG、 HbA1c、IL-1β、IL-6水平比较，差异均无统计学意义（P＞0.05）。治疗后，两组患者FPG、2 h PG、HbA1c、IL-1β、IL-6水平均显著低于同组治疗前，且观察组低于对照组，差异均有统计学意义（P＜0.05）。两组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：在常规治疗的基础上，参芪降糖颗粒辅助治疗2型糖尿病性膝关节炎的疗效显著，可降低血糖及炎症因子水平，且不良反应症状轻微。 |
| ABSTRACT： | OBJECTIVE： To observe the efficacy and safety of Shenqi jiangtang granule in the adjuvant treatment of type 2 diabetes knee arthritis. METHODS： 62 patients with type 2 diabetes knee arthritis were randomly divided into control group （31 cases） and observation group （31 cases）. Control group received hypoglycemic and basic treatment for arthritis， including diet control， exercise therapy and health education， as well as 0.25 g Metformin hydrochloride tablet with a meal， 3 times a day + 50 mg Acarbose tablet with a meal， 3 times a day， chewing； patients with arthritis pain 100 mg Aspirin enteric-coated tablet after a meal， once a day （chewing or breaking apart was prohibited）. Observation group additionally received 3 g Shenqi jiangtang granule half an hour before a meal with 50 ml warm water， 3 times a day. The treatment course for both groups was 6 months. Clinical efficacy， and fasting plasma glucose （FPG）， 2 h postprandial blood glucose （2 h PG）， glycated hemoglobin （HbA1c）， interleukin -1β （IL-1β）， IL-6 before and after treatment， and the incidence of adverse reactions in 2 groups were observed. RESULTS： The total effective rate in observation group was significantly higher than control group， the difference was statistically significant （P＜0.05）. Before treatment， there were no significant differences in the FPG， 2 h PG， HbA1c， IL-1β and IL-6 between 2 groups （P＞0.05）. After treatment， FPG， 2 h PG， HbA1c， IL-1β and IL-6 in 2 groups were significantly lower than before， and observation group was lower than control group， the differences were statistically significant （P＜0.05）. And there was no significant in the incidence of adverse reactions between 2 groups （P＞0.05）. CONCLUSIONS： Based on conventional treatment， Shenqi jiangtang granule shows obvious efficacy in the adjuvant treatment of type 2 diabetes knee arthritis.， it can reduce blood glucose and inflammation cytokine levels， mild symptoms of adverse reactions. |
| 期刊： | 2016年第27卷第24期 |
| 作者： | 张鸽，燕丽君，刘铜龙，黄炜，李春君，于德民 |
| AUTHORS： | ZHANG Ge，YAN Lijun，LIU Tonglong，HUANG Wei，LI Chunjun，YU Demin |
| 关键字： | 参芪降糖颗粒；辅助治疗；2型糖尿病性膝关节炎；疗效；安全性 |
| KEYWORDS： | Shenqi jiangtang granule； Adjuvant treatment； Type 2 diabetes knee arthritis； Efficacy； Safety |
| 阅读数： | 235 次 |
| 本月下载数： | 2 次 |
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