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地塞米松不同给药方式治疗分泌性中耳炎的临床观察
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| 篇名： | 地塞米松不同给药方式治疗分泌性中耳炎的临床观察 |
| TITLE： | |
| 摘要： | 目的 ：观察地塞米松不同给药方式治疗分泌性中耳炎的疗效和安全性。 方法： 回顾性收集92例分泌性中耳炎患者资料，按给药方式的不同分为观察组（43例）和对照组（49例）。观察组患者于电子鼻咽喉镜辅助下经咽鼓管内注射地塞米松磷酸钠注射液5 mg，每2日1次。对照组患者于鼓膜穿刺鼓室内注射地塞米松磷酸钠注射液5 mg，每2日1次。两组均以7 d为1个治疗周期，未痊愈者可再治疗1个周期，最多可重复治疗4个周期。观察两组患者的临床疗效，治疗前后的肿瘤坏死因子（TNF）-α、C-反应蛋白（CRP）、白细胞介素（IL）-6、IL-10水平，痊愈后1年累积复发率及不良反应发生情况。结果：观察组患者总有效率显著高于对照组，痊愈后1年累积复发率显著低于对照组，差异均有统计学意义（P＜0.05）。治疗前，两组患者TNF-α、CRP、IL-6、IL-10比较，差异均无统计学意义（P＞0.05）。治疗后，两组患者TNF-α、IL-6水平均显著低于同组治疗前，且观察组低于对照组，差异均有统计学意义（P＜0.05）；两组患者治疗前后CRP、IL-10水平比较，差异均无统计学意义（P＞0.05）。两组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：电子鼻咽喉镜辅助下经咽鼓管内注射地塞米松的疗效显著优于鼓膜穿刺鼓室内给药，可降低复发率，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To observe the efficacy and safety of different administration of dexamethasone in the treatment of secretory otitis media. METHODS： Data of 92 patients with secretory otitis media was retrospectively collected and divided into observation group （43 cases） and control group （49 cases） by different administration. Observation group received 5 mg Dexamethasone injection by injection in the eustachian tube in the assisted by video laryngoscope， once every 2 day. Control group received 5 mg Dexamethasone injection by injection in the eustachian tube， once every 2 day. 7-day was regarded as 1 treatment course. 1 more course for uncured patients， and no more than 4 courses. Clinical efficacy， and tumor necrosis factor-α（TNF-α）， C-reactive protein （CRP）， interleukin-6（IL-6），IL-10 levels before and after treatment， and 1-year cumulative recurrence rate after cured and the incidence of adverse reactions in 2 groups were observed. RESULTS： The total effective rate in observation group was significantly higher than control group， 1-year cumulative recurrence rate after cured was significantly lower than control group， the differences were statistically significant （P＜0.05）. Before treatment， there were no significant differences in TNF-α， CRP， IL-6 and IL-10 levels between 2 groups （P＞0.05）. After treatment， TNF-α and IL-6 level in 2 groups were significantly lower than before， and observation group was lower than control group， the differences were statistically significant （P＜0.05）； there were no significant differences in CRP and IL-10 between 2 groups before and after treatment （P＞0.05）. And there was no significant difference in the incidence of adverse reactions between 2 groups （P＞0.05）. CONCLUSIONS： The efficacy of dexamethasone by injection in the eustachian tube in the assisted by electron-nasopharyngolaryngoscopy is superior to auripuncture administration， it can reduce recurrence rate， with good safety. |
| 期刊： | 2016年第27卷第24期 |
| 作者： | 张宇丽，尹桂茹，毕静，齐智伟，张淑君 |
| AUTHORS： | ZHANG Yuli，YIN Guiru，BI Jing，QI Zhiwei，ZHANG Shujun |
| 关键字： | 分泌性中耳炎；地塞米松；鼓膜穿刺；电子鼻咽喉镜 |
| KEYWORDS： | Secretory otitis media； Dexamethasone； Auripuncture； Electron-nasopharyngolaryngoscopy |
| 阅读数： | 621 次 |
| 本月下载数： | 3 次 |
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