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盐酸氨溴索治疗新生儿呼吸窘迫综合征的临床观察
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| 篇名： | 盐酸氨溴索治疗新生儿呼吸窘迫综合征的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察盐酸氨溴索治疗新生儿呼吸窘迫综合征的临床疗效及安全性。方法：选取新生儿呼吸窘迫综合征患儿108例，按照随机数字表法分为对照组和观察组，各54例。对照组患儿给予吸氧通气、抗感染及营养支持等常规治疗，观察组患儿在对照组基础上加用盐酸氨溴索注射液30 mg/kg，ivgtt，qd，连续治疗4～6 d。比较两组患儿的临床疗效，治疗后12、24、48 h的血气指标[氧分压（PaO2）、二氧化碳分压（PaCO2）]，临床症状缓解时间、住院时间、X片分值、潮气量（VT）及动态肺顺应性（Cdyn）的变化情况，并观察不良反应发生情况。结果：观察组患儿临床总有效率为94.44％，显著高于对照组的51.85％，差异有统计学意义（P＜0.05）。治疗后12 h两组患儿血气指标比较，差异无统计学意义（P＞0.05）；治疗后24、48 h，观察组患儿PaO2明显高于对照组，PaCO2明显低于对照组，差异均有统计学意义（P＜0.05）。观察组患儿发绀、呼吸困难、肺部湿啰音缓解时间及住院时间均明显短于对照组，差异有统计学意义（P＜0.05）。观察组患儿治疗后X片分值、Cdyn及VT水平均明显高于对照组，差异有统计学意义（P＜0.05）。观察组患儿不良反应发生率为3.70％，显著低于对照组的18.52％，差异有统计学意义（P＜0.05）。结论：盐酸氨溴索治疗新生儿呼吸窘迫综合征疗效显著，能明显改善患儿血气指标，加快疾病康复，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To observe the clinical efficacy and safety of ambroxol hydrochloride in the treatment of neonatal respiratory distress syndrome. METHODS： 108 cases of neonatal respiratory distress syndrome were randomly divided into control group and observation group， 54 cases in each group. Control group were treated with conventional treatment， such as oxygen inhalation， anti-infection and nutritional support， observation group was additionally treated with 30 mg/kg Ambroxol hydrochloride injection， ivgtt， qd， for continuous treatment of 4-6 d. Clinical efficacy， blood gas indexes [oxygen partial pressure （PaO2）， carbon dioxide partial pressure （PaCO2）]， 12， 24 and 48 h after treatment remission time of clinical symptoms， hospitalization time， changes of X-ray film value， tidal volume （VT） and dynamic lung compliance （Cdyn） in 2 groups were compared， and the incidence of adverse reactions was observed. RESULTS： The total effective rate in observation group was 94.44％， which was significantly higher than control group （51.58％）， the difference was statistically significant （P＜0.05）； there was no significant difference in the blood gas indexes in observation group after 12 h （P＞0.05）， PaO2 was significantly higher than control group and PaCO2 was significantly lower than control group 24 and 48 h after treatment， there was significant difference between 2 groups （P＜0.05）. Remission time of cyanosis， dyspnea， lung moist rales and hospitalization time in observation group were shorter than control group， the difference was statistically significant （P＜0.05）. X-ray film value， Cdyn and VT levels in observation group were significantly higher than control group， the difference was statistically significant （P＜0.05）. The incidence of adverse reactions in observation group was 3.70％， which was significantly lower than control group （18.52％）， the difference was statistically significant （P＜0.05）. CONCLUSIONS： Ambroxol hydrochloride shows obvious efficacy in the treatment of neonatal respiratory distress syndrome， it can improve blood gas indexes and accelerate the recovery from disease， with good safety. |
| 期刊： | 2016年第27卷第23期 |
| 作者： | 史钟慧，邱立志，陈玉才 |
| AUTHORS： | SHI Zhonghui，QIU Lizhi，CHEN Yucai |
| 关键字： | 盐酸氨溴索；新生儿呼吸窘迫综合征；临床疗效；安全性 |
| KEYWORDS： | Ambroxol hydrochloride； Neonatal respiratory distress syndrome； Clinical efficacy； Safety |
| 阅读数： | 333 次 |
| 本月下载数： | 2 次 |
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