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硫酸镁联合硫酸沙丁胺醇雾化吸入治疗小儿重度支气管哮喘急性发作的临床观察
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| 篇名： | 硫酸镁联合硫酸沙丁胺醇雾化吸入治疗小儿重度支气管哮喘急性发作的临床观察 |
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| 摘要： | 目的：探讨硫酸镁联合硫酸沙丁胺醇雾化吸入治疗小儿重度支气管哮喘急性发作的临床疗效及安全性。方法：85例重度支气管哮喘急性发作患儿按照就诊单双日分为对照组（45例）与干预组（40例）。在静脉注射糖皮质激素、吸氧、镇静、营养支持等基础治疗的基础上，对照组患儿雾化吸入硫酸沙丁胺醇，每次0.6 ml，每20 min一次，共治疗l h；干预组患儿在对照组治疗基础上雾化吸入硫酸镁，每次0.6 ml，每20 min一次，共治疗l h。观察两组患儿用药1 h后的临床疗效、体检指标（气短、哮鸣音、咳嗽）改善时间、肺功能指标及不良反应，并记录出院时间。结果：干预组患儿用药1 h后的总有效率为95.00％，明显高于对照组的77.78％，差异具有统计学意义（P＜0.05）；干预组患儿的气短、哮鸣音、咳嗽改善时间以及出院时间均明显短于对照组，差异均有统计学意义（P＜0.05）；干预组患儿的最大呼气流量、1秒用力呼气容积较对照组均有显著改善，差异均有统计学意义（P＜0.05）。两组均有患儿出现轻微不良反应，不良反应发生率组间比较差异无统计学意义（P＞0.05）。结论：在常规治疗基础上，采用硫酸镁联合硫酸沙丁胺醇雾化吸入治疗小儿重度支气管哮喘急性发作具有较好的临床疗效，且安全性较高。 |
| ABSTRACT： | OBJECTIVE： To investigate the clinical efficacy and safety of aerosol inhalation of magnesium sulfate and salbutamol sulfate in the treatment of acute attack of severe bronchial asthma in children. METHODS： 85 children with acute attack of severe bronchial asthma were divided into control group （45 cases） and intervention group （40 cases） in accordance to even and odd number of hospitalization time. Based on routine treatment of glucocorticoid intravenous injection， oxygen uptake， sedation and nutritional support， control group was given aerosol inhalation of salbutamol sulfate， 0.6 ml each time， once every 20 min， for 1 h； intervention group was additionally given aerosol inhalation of magnesium sulfate， 0.6 ml each time， once every 20 min， for 1 h， on the basis of control group. Therapeutic efficacy， improvement time of shortness of physical examination indexes （breath， wheeze， coughing）， lung function indicators and ADR were observed in 2 groups， and discharge time was recorded in 2 groups. RESULTS： The total effective rate of clinical efficacy of intervention group was 95.00％ after 1 h treatment， which was significantly higher than 77.78％ in control group， with statistical significance （P＜0.05）； the time of shortness of breath improvement， wheeze improvement， coughing improvement and discharge in intervention group were significantly shorter than in control group， with statistical significance （P＜0.05）； PEF and FEV1 of intervention group were improved significantly compared to control group， with statistical significance （P＜0.05）. Both groups suffered from slight ADR， there was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： On the basis of conventional treatment， the aerosol inhalation of magnesium sulfate and salbutamol sulfate shows good clinical efficacy and safety in the treatment of acute attack of severe bronchial asthma in children. |
| 期刊： | 2016年第27卷第23期 |
| 作者： | 羊礼荣，顾倩，杨晓光，吴娟 |
| AUTHORS： | YANG Lirong，GU Qian，YANG Xiaoguang，WU Juan |
| 关键字： | 硫酸镁；硫酸沙丁胺醇；重度支气管哮喘；急性发作；儿童 |
| KEYWORDS： | Magnesium sulfate； Salbutamol sulfate； Severe bronchial asthma； Acute attack； Children |
| 阅读数： | 380 次 |
| 本月下载数： | 3 次 |
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