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49例质子泵抑制剂酸反跳的临床观察及影响因素分析
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| 篇名： | 49例质子泵抑制剂酸反跳的临床观察及影响因素分析 |
| TITLE： | |
| 摘要： | 目的：探讨质子泵抑制剂酸反跳的影响因素。方法：抽取我院2015年1－12月使用质子泵抑制剂达1月的患者109例，自停药起后1周进行电话回访，录入患者产生的上消化系统反应数据，并按照改良格拉斯哥消化不良评分进行评分，分为无现象组（分数＜5分）和质子泵抑制剂酸反跳组（分数≥5分）。将患者按照基础疾病、年龄、性别、是否有吸烟饮酒史分类，进行质子泵抑制剂酸反跳现象观察及分析。结果：完成调查患者91例，其中49例患者归入质子泵抑制剂酸反跳组。通过χ2检验发现，老年患者 （χ2＝5.350，P＝0.021）、有吸烟饮酒史患者（χ2＝4.351，P＝0.037） 质子泵抑制剂酸反跳发生率较高；排除性别、基础疾病影响，通过Logistic回归分析发现，老年患者质子泵抑制剂酸反跳的风险是非老年患者的5.708倍[OR＝5.708，95％CI（1.946，16.746），P＝0.002]；有吸烟饮酒史患者质子泵抑制剂酸反跳的风险是无吸烟饮酒史患者的15.281倍[OR＝15.281，95％CI（2.748，84.965），P＝0.002]，差异均有统计学意义（P＜0.05）。结论：质子泵抑制剂停药后，部分患者会产生酸反跳现象，而老年患者、有吸烟饮酒史患者是高发人群，应引起重视。 |
| ABSTRACT： | OBJECTIVE： To investigate the acid rebound in proton pump inhibitors （PPIs） and its influential factors. METHODS： Totally 109 patients who treated with PPIs for 1 month in our hospital during Jan. -Dec. 2015 were collected， and telephone visit was conducted after 1 week withdrawal to the data of dyspeptic symptoms were input and scored by modified Glasgow Dyspepsia Sererity Score， then divided into no phenomenon group （＜5 scores） and acid rebound in proton pump inhibitors group （≥5 scores）. All patients were classified by basic diseases， age， gender， whether smoking and alcohol drinking， and phenomenon of acid rebound in PPIs were observed and analyzed. RESULTS： Totally 91 patients were observed， 49 were classified as acid rebound in PPIs group. χ2 test showed elderly patients （χ2＝5.350，P＝0.021） and people with smoking and alcohol drinking （χ2＝4.351，P＝0.037） were associated with the increased risk of acid rebound in PPIs； exclusion of the effects of gender and basic disease， Logistic regression analysis showed the risk of acid rebound in PPIs in elderly patients were 5.708 times to non-elderly patients [OR＝5.708，95％CI（1.946，16.746），P＝0.002]； people with smoking and alcohol drinking was 15.281 times to non-smoking and alcohol drinking [OR＝15.281，95％CI（2.748，84.965），P＝0.002]， the difference was statistically significant （P＜0.05）. CONCLUSIONS： Parts of patients show acid rebound after stopping PPIs， while elderly patients and patients with smoking and alcohol drinking are the high-risk population， which should be paid attention to. |
| 期刊： | 2016年第27卷第23期 |
| 作者： | 张萃鳌，王琳，任雪松，王亚新，杨英，袁瑕 |
| AUTHORS： | ZHANG Cui’ao，WANG Lin，REN Xuesong，WANG Yaxin，YANG Ying，YUAN Xia |
| 关键字： | 质子泵抑制剂；酸反跳；影响因素；临床观察 |
| KEYWORDS： | Proton pump inhibitors； Acid rebound； Influential factor； Clinical observation |
| 阅读数： | 593 次 |
| 本月下载数： | 2 次 |
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