37例精神分裂症患者棕榈酸帕利哌酮注射液血药浓度监测及其影响因素分析-中国药房

37例精神分裂症患者棕榈酸帕利哌酮注射液血药浓度监测及其影响因素分析

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篇名：	37例精神分裂症患者棕榈酸帕利哌酮注射液血药浓度监测及其影响因素分析
TITLE：
摘要：	目的：探讨精神分裂症患者棕榈酸帕利哌酮注射液血药浓度监测的影响因素。方法：选择无锡市精神卫生中心2012年9月－2015年6月使用棕榈酸帕利哌酮注射液，并进行血药浓度监测的精神分裂症患者37例，对其监测结果进行统计、分析，初步探讨其影响因素。结果：共监测棕榈酸帕利哌酮血药浓度37次，平均血药浓度（以帕利哌酮计）为（17.72±13.46）ng/ml，监测结果在目标值范围内（10～60 ng/ml）的有24次（64.86％）；男性患者平均血药浓度低于女性患者，差异有统计学意义（P＜0.05）；不同年龄段患者平均血药浓度间的差异无统计学意义（P＞0.05）；不同日剂量患者血药浓度/剂量比间的差异无统计学意义（P＞0.05）；联合用药的患者平均血药浓度高于单药治疗的患者，差异有统计学意义（P＜0.05）；疗效判定为“缓解”的患者平均血药浓度与“无效”的患者比较，差异无统计学意义（P＞0.05）。结论：帕利哌酮血药浓度受患者年龄及联合用药等因素的影响，临床可根据血药浓度监测结果及患者症状优化治疗方案，促进合理用药。
ABSTRACT：	OBJECTIVE： To explore the influential factors for plasma concentration of paliperidone palmitate injection for patients with schizophrenia. METHODS： 37 schizophrenia patients who used Paliperidone palmitate injection and took plasma concentration monitoring in Wuxi Mental Health Center from Sept. 2012 to Jun. 2015 was selected， the results were statistically analyzed， and the influential factors were preliminary explored. RESULTS： Totally 37 times were conducted for the plasma concentration monitoring for paliperidone with the average plasma concentration of （17.72±13.46） ng/ml， and 24 times （accounting for 64.86％） in the range of （10-60 ng/ml）； the average plasma concentration of male patients was lower than that of female patients， the difference was statistically significant （P＜0.05）； there was no significant difference in the average plasma concentration among different ages （P＞0.05）； there was also no significant difference in plasma concentration/dose ratio in patients with different daily dose （P＞0.05）； the average plasma concentration of patients with combination treatment was higher than that of single drug， the difference was statistically significant （P＜0.05）； and there was no significant difference in the average plasma concentration of relieved patients and ineffective treatment patients （P＞0.05）. CONCLUSIONS： The plasma concentration of paliperidone palmitate is affected by age， combination treatment and other factors， clinic can optimize the therapeutic regimen based on monitoring results of plasma concentration and patients’ symptoms to promote the rational drug use.
期刊：	2016年第27卷第23期
作者：	曲衎衎，沈珍贤，张忠东
AUTHORS：	QU Kankan，SHEN Zhenxian，ZHANG Zhongdong
关键字：	棕榈酸帕利哌酮注射液；血药浓度；性别；年龄；日剂量；联合用药；精神分裂症
KEYWORDS：	Paliperidone palmitate injection； Plasma concentration； Gender； Age； Daily dosage； Drug combination； Schizophrenia
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