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左氧氟沙星和曲安奈德双载药眼用凝胶的制备
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| 篇名： | 左氧氟沙星和曲安奈德双载药眼用凝胶的制备 |
| TITLE： | |
| 摘要： | 目的：制备左氧氟沙星和曲安奈德双载药眼用凝胶。方法：以盐酸左氧氟沙星和醋酸曲安奈德为主药、卡波姆940P为凝胶基质、羟丙甲纤维素（HPMC K4M）为增黏剂，制备左氧氟沙星和曲安奈德双载药眼用凝胶。以凝胶的溶散时间为指标，采用单因素试验筛选处方中卡波姆940P和HPMC K4M的浓度；测定所制双载药眼用凝胶的溶散时间、黏度和2种主药的含量。结果：双载药眼用凝胶处方中卡波姆940P的浓度为0.4％、HPMC K4M的浓度为1.2％。所制双载药眼用凝胶的溶散时间不低于24 h，黏度为1 142.67 Pa·s；盐酸左氧氟沙星含量占标示量的97.3％（RSD＝0.84％，n＝3），醋酸曲安奈德含量占标示量的92.97％（RSD＝1.32％，n＝3）。结论：成功制得左氧氟沙星和曲安奈德双载药眼用凝胶。 |
| ABSTRACT： | OBJECTIVE： To prepare Levofloxacin and triamcinolone acetonide double-loaded ophthalmic gel. METHODS： Using levofloxacin hydrochloride and triamcinolone acetonide as main components， carbopol-940P as base material， HPMC K4M as tackifier， Levofloxacin and triamcinolone acetonide double-loaded ophthalmic gel was prepared. Using dissolution time as index， the contents of carbopol-940P and HPMC K4M were determined by single factor test， and dissolution time， viscosity and the contents of 2 main components were also determined. RESULTS： The concentrations of carbopol-940P and HPMC K4M were 0.4％ and 1.2％， separately. The dissolution time was more than 24 h and viscosity was 1 142.67 Pa·s. The content of levofloxacin hydrochloride was 97.3％ of labelled amount （RSD＝0.84％， n＝3）， and that of triamcinolone acetonide was 92.97％ of labelled amount （RSD＝1.32％， n＝3）. CONCLUSIONS： Levofloxacin and triamcinolone acetonide double-loaded ophthalmic gel has been prepared successfully. |
| 期刊： | 2016年第27卷第22期 |
| 作者： | 樊莲莲，杨青青，徐翰林，张培雯，苏文成，黄亚，陈宏 |
| AUTHORS： | FAN Lianlian，YANG Qingqing，XU Hanlin，ZHANG Peiwen，SU Wencheng，HUANG Ya，CHEN Hong |
| 关键字： | 左氧氟沙星；曲安奈德；眼用凝胶 |
| KEYWORDS： | Levofloxacin； Triamcinolone acetonide； Ophthalmic gel |
| 阅读数： | 407 次 |
| 本月下载数： | 3 次 |
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