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玉屏风散对肺气虚证模型大鼠免疫功能的影响
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| 篇名： | 玉屏风散对肺气虚证模型大鼠免疫功能的影响 |
| TITLE： | |
| 摘要： | 目的：考察玉屏风散对肺气虚证模型大鼠免疫功能的影响。方法：将60只SD大鼠随机分为正常组、模型组、阳性组[人参北芪片0.6 g（生药）/kg]和玉屏风散高、中、低剂量组[24、12、6 g（生药）/kg]，每组10只。除正常组外，其余各组大鼠均采用二氧化硫+风寒综合刺激法复制肺气虚证模型。造模成功后，各给药组大鼠ig相应药液，正常组和模型组大鼠ig等体积生理盐水，每天1次，连续13 d。给药结束后，测定大鼠血清中白细胞介素（IL）-3、IL-6水平及T淋巴细胞中CD3+、CD4+、CD8+比例，观察肺、支气管组织病理变化。结果：与正常组比较，模型组大鼠血清中IL-3、IL-6水平及T淋巴细胞中CD8+比例明显升高，T淋巴细胞中CD3+、CD4+比例及CD4+/CD8+比值降低（P＜0.01）；肺、支气管明显损伤并伴有炎症反应。与模型组比较，阳性组和玉屏风散高剂量组大鼠血清中IL-3水平明显降低；阳性组和玉屏风散高、中剂量组大鼠血清中IL-6水平、T淋巴细胞中CD8+比例明显降低，T淋巴细胞中CD3+比例明显升高；各给药组大鼠血清中CD4+比例、CD4+/CD8+比值明显升高（P＜0.05或P＜0.01）；肺、支气管损伤及炎症反应程度减轻。结论：玉屏风散可增强肺气虚证模型大鼠的免疫功能。 |
| ABSTRACT： | OBJECTIVE： To study the effects of Yupingfeng powder on immune function of rats with lung-qi deficiency syndrome. METHODS： 60 SD rats were randomly divided into normal group， model group， positive group [Renshen beiqi tablet 0.6 g （crude drug）/kg] and Yupingfeng powder high-dose， medium-dose and low-dose groups [24， 12， 6 g （crude drug）/kg]， with 10 rats in each group. Except for normal group， those groups were given SO2+comprehensive cold stimulation to induce lung-qi deficiency syndrome model. After modeling， treatment groups were given relevant drug solutions intragastrically， and normal group and model group were given constant volume of normal saline intragastrically， once a day， for consecutive 13 d. After administration， serum levels of IL-3 and IL-6， the proportion of CD3+， CD4+， CD8+ in T lymphocyte were determined， and pathological changes of lung and bronchus were observed. RESULTS： Compared with normal group， serum levels of IL-3 and IL-6 and the proportion of CD8+ in T lymphocyte increased significantly in model group， while the proportions of CD3+ and CD4+ in T lymphocyte and the ratio of CD4+/CD8+ decreased （P＜0.01）； obvious lung and bronchus injury and inflammatory reaction were observed. Compared with model group， serum level of IL-3 decreased significantly in positive group and Yupingfeng powder high-dose group； serum level of IL-6 and the proportion of CD8+ in T lymphocyte decreased significantly in positive group and Yupingfeng powder high-dose and medium-dose groups， while the proportion of CD3+ in T lymphocyte increased significantly； the proportion of CD4+ and the ratio of CD4+/CD8+ increased significantly in treatment groups （P＜0.05 or P＜0.01）； lung and bronchial injury， and inflammation reaction were relieved. CONCLUSIONS： Yupingfeng powder can enhance immune function of rats with lung-qi deficiency syndrome. |
| 期刊： | 2016年第27卷第22期 |
| 作者： | 杨胜，张仲林，袁明勇，郑玲利，李燕，廖昌军 |
| AUTHORS： | YANG Sheng，ZHANG Zhonglin，YUAN Mingyong，ZHENG Lingli，LI Yan，LIAO Changjun |
| 关键字： | 玉屏风散；肺气虚证；免疫功能；T淋巴细胞；大鼠 |
| KEYWORDS： | Yupingfeng powder； Lung-qi deficiency； Immune function； T lymphocyte； Rats |
| 阅读数： | 336 次 |
| 本月下载数： | 5 次 |
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