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奥氮平与喹硫平治疗老年期精神病的临床观察
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| 篇名： | 奥氮平与喹硫平治疗老年期精神病的临床观察 |
| TITLE： | |
| 摘要： | 目的：比较奥氮平与喹硫平治疗老年期精神病的临床疗效及安全性。方法：将120例老年期精神病患者按随机数字表法分为奥氮平组和喹硫平组，各60例。奥氮平组患者口服奥氮平片，初始剂量2.5 mg，qd，根据病情可增至最大剂量15 mg，qd；喹硫平组患者口服喹硫平片，初始剂量50 mg，qd，根据病情可增至最大剂量400 mg，qd。两组患者均治疗6周。比较两组患者治疗前后阳性和阴性症状量表（PANSS）评分、生活质量评分及临床疗效，并观察不良反应发生情况。结果：两组患者治疗后PANSS评分、生活质量评分均显著改善，差异均有统计学意义（P＞0.05），但组间比较差异无统计学意义（P＞0.05）。两组患者临床疗效比较，差异无统计学意义（P＞0.05）。喹硫平组患者嗜睡、低血压、心动过缓发生率显著低于奥氮平组，心动过速发生率显著高于奥氮平组，差异有统计学意义（P＜0.05）。结论：奥氮平与喹硫平治疗老年期精神病疗效相当，均可显著改善患者生活质量，但喹硫平不良反应较奥氮平轻。 |
| ABSTRACT： | OBJECTIVE： To compare clinical efficacy and safety of olanzapine and quetiapine for mental disorders elderly patients. METHODS： 120 elderly patients with mental disorders were randomly divided into olanzapine group and quetiapine group， with 60 cases in each group. Olanzapine group was given Olanzapine tablet orally with initial dose of 2.5 mg， qd， and then increasing to maximal dose 15 mg according to disease condition， qd； quetiapine group was given Quetiapine tablet orally with initial dose of 50 mg， qd， increasing to maximal dose 400 mg according to disease condtion， qd. Both groups received 6 weeks of treatment. Clinical efficacy of 2 groups were compared as well as PANSS and the quality score of life before and after treatment， and the occurrence of ADR. RESULTS： PANSS and the quality score of life were improved significantly in both groups， with statistical significance （P＞0.05）； but there was no statistical significance between 2 groups （P＞0.05）. There was no statistical significance in clinical efficacy between 2 groups （P＞0.05）. The incidence of lethargy， hypotension and bradycardia in quetiapine group were significantly lower than in olanzapine group， while the incidence of tachycardia was significantly higher than olanzapine group， with statistical significance （P＜0.05）. CONCLUSIONS： Olanzapine and quetiapine are similar to each other in the treatment of mental disorders elderly patients； both of them can effectively improve the quality of life， and ADR induced by quetiapine is slighter than that induced by olanzapine. |
| 期刊： | 2016年第27卷第20期 |
| 作者： | 马敬，王宁，石玉中 |
| AUTHORS： | MA Jing，WANG Ning，SHI Yuzhong |
| 关键字： | 奥氮平；喹硫平；老年；精神病 |
| KEYWORDS： | Olanzapine； Quetiapine； Elderly； Mental disorders |
| 阅读数： | 467 次 |
| 本月下载数： | 5 次 |
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