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卡培他滨辅助放疗对Ⅱ～Ⅲ期直肠癌老年患者术后生存和复发情况的影响
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| 篇名： | 卡培他滨辅助放疗对Ⅱ～Ⅲ期直肠癌老年患者术后生存和复发情况的影响 |
| TITLE： | |
| 摘要： | 目的：观察卡培他滨辅助放疗对Ⅱ～Ⅲ期直肠癌老年患者术后生存率、复发率、生存质量的影响及安全性。方法：选取Ⅱ～Ⅲ期直肠癌老年患者共110例，按随机数字表法分为对照组和观察组，各55例。两组患者均行直肠癌根治术。对照组患者术后给予三维适形放疗；观察组患者在对照组基础上加用卡培他滨d1～14，1 500 mg/m2，qd。21 d为1个周期，两组患者均治疗2个周期，随访3年。比较两组患者随访生存率、转移复发率及治疗前后卡氏（KPS）评分，并观察两组患者毒副反应。结果：观察组患者随访3年总生存率和无病生存率分别为89.09％和76.36％，显著高于对照组的74.55％和54.55％，远处转移率和局部复发率分别为12.73％和5.45％，显著低于对照组的30.91％和21.82％，差异均有统计学意义（P＜0.05）。两组患者治疗后KPS评分显著升高，治疗前后比较，差异有统计学意义（P＜0.05）；组间比较，差异无统计学意义（P＞0.05）。对照组患者恶心呕吐、腹泻及泌尿生殖系统毒副反应发生率比较，差异无统计学意义（P＞0.05）；但观察组患者骨髓抑制发生率显著高于对照组（P＜0.05）。结论：卡培他滨辅助三维适形放疗能有效提高Ⅱ～Ⅲ期老年直肠癌患者术后生存率，降低转移复发风险，且未导致生存质量下降及严重毒副反应发生。 |
| ABSTRACT： | OBJECTIVE： To observe the influence of capecitabine combined with radiotherapy on postoperative survival rate， relapse rate and survival quality of elderly patients with rectal cancer at Ⅱ-Ⅲ stage. METHODS： 110 patients with rectal cancer at Ⅱ-Ⅲ stage were selected and randomly divided into control group and observation group with 55 cases in each group. Both group received radical resection of rectal carcinoma. Control group was given three dimensional conformal radiation therapy （3DCRT） after operation； observation group was additionally given capecitabine 1 500 mg/m2， d1-14， qd， on the basis of control group. A treatment course lasted for 21 d， and both groups received 2 courses of treatment and followed up for 3 years. The survival rate and metastasis and recurrence rate of 2 groups were compared as well as KPS score before and after treatment. Toxic reaction of 2 groups was also observed. RESULTS： The follow-up total survival rate and disease-free survival rate of observation group were 89.09％ and 76.36％， which were significantly higher than 74.55％ and 54.55％ of control group； the distant metastasis rate and local recurrence rate were 12.73％ and 5.45％， which were significantly lower than 30.91％ and 21.82％， with statistical significance （P＜0.05）. KPS score of 2 groups were increased significantly， between 2 groups before and after treatment ，with statistical significance （P＜0.05）； Comparison between groups （P＞0.05）. There was no statistical significance in the incidence of nausea and vomiting， diarrhea and urinary tract reaction between 2 groups （P＞0.05）； but the incidence of bone marrow arrest in observation group was significantly higher than control group（P＜0.05）. CONCLUSIONS： Capecitabine combined with 3DCRT can effectively improve postoperative distant survival rate of patients with rectal cancer at Ⅱ-Ⅲ stage， and reduce the metastasis and recurrence risk； do not lower life quality and induce serious adverse reactions. |
| 期刊： | 2016年第27卷第20期 |
| 作者： | 徐靖，吴慧，王姝娟 |
| AUTHORS： | XU Jing，WU Hui，WANG Shujuan |
| 关键字： | 卡培他滨；三维适形放疗；直肠癌 |
| KEYWORDS： | Capecitabine；Three dimensional conformal radiation therapy；Rectal cancer |
| 阅读数： | 308 次 |
| 本月下载数： | 2 次 |
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