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脉络宁注射液联合贝那普利治疗慢性肾小球肾炎的临床观察
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| 篇名： | 脉络宁注射液联合贝那普利治疗慢性肾小球肾炎的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察脉络宁注射液联合贝那普利治疗慢性肾小球肾炎（CGN）的临床疗效及安全性。方法：将130例CGN患者按随机数字表法分为观察组与对照组，各65例。两组患者均给予低盐、低脂等常规治疗。对照组患者在此基础上给予贝那普利片10 mg，qd；观察组在对照组的基础上给予脉络宁注射液20 ml加入5％氯化钠注射液250 ml中，ivgtt，qd，每连续给药10 d后停药20 d。两组患者均治疗4个月。观察两组患者临床疗效及治疗前后尿素氮（BUN）、尿肌酐（UCr）、血肌酐（SCr）及24小时尿蛋白定量水平，并比较不良反应发生率。结果：观察组患者临床总有效率为83.1％，显著高于对照组的67.7％，差异有统计学意义（P＜0.05）。两组患者治疗前BUN、UCr、SCr及24小时尿蛋白定量水平比较，差异无统计学意义（P＞0.05）；两组患者治疗后BUN、UCr、SCr及24小时尿蛋白定量水平均显著降低，且观察组显著低于对照组，差异均有统计学意义（P＜0.05）。两组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：脉络宁注射液联合贝那普利治疗CGN疗效显著，能有效改善患者肾脏功能，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To observe clinical efficacy and safety of Mailuoning injection combined with benazepril in the treatment of chronic glomerulonephritis. METHODS： 130 patients with chronic glomerulonephritis were randomly divided into observation group and control group， with 65 cases in each group. Both groups received rountine treatment as low salt and fat diet. Control group was additionally given Benazepril tablet 10 mg， qd； observation group was additionally given Mailuoning injection 20 ml added into 5％ Sodium chloride injection 250 ml， ivgtt， qd， on the basis of control group， 20 days of drug withdrawal every 10 days. Both group received 4 months of treatment. Clinical efficacy of 2 groups were observed as well as the levels of BUN， UCr， SCr and 24 h urine protein quantitative （UPE） before and after the treatment. The incidence of ADR was compared between 2 groups. RESULTS： Total effective rate of observation group was 83.1％， which was significantly higher than 67.7％ of control group， with statistical significance （P＜0.05）. There was no statistical significance in BUN， UCr， SCr and 24 h UPE between 2 groups before treatment （P＞0.05）； those indexes of 2 groups decreased significantly after treatment， and the observation group were lower than the control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Mailuoning injection combined with benazepril is effective for chronic glomerulonephritis， and can effectively improve renal function with good safety. |
| 期刊： | 2016年第27卷第20期 |
| 作者： | 朱春玲，胡春芳，王代宏，夏秀丹，姜琼，陈勇，赵克栋 |
| AUTHORS： | ZHU Chunling，HU Chunfang，WANG Daihong，XIA Xiudan，JIANG Qiong，CHEN Yong，ZHAO Kedong |
| 关键字： | 脉络宁注射液；贝那普利；慢性肾小球肾炎；疗效；安全性 |
| KEYWORDS： | Mailuoning injection； Benazepril； Chronic glomerulonephritis； Efficacy； Safety |
| 阅读数： | 229 次 |
| 本月下载数： | 2 次 |
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