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鼻渊通窍颗粒联合曲安奈德鼻喷雾剂治疗慢性鼻-鼻窦炎的临床观察
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| 篇名： | 鼻渊通窍颗粒联合曲安奈德鼻喷雾剂治疗慢性鼻-鼻窦炎的临床观察 |
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| 摘要： | 目的：观察鼻渊通窍颗粒联合曲安奈德鼻喷雾剂治疗慢性鼻-鼻窦炎的临床疗效及安全性。方法：将120例慢性鼻-鼻窦炎患者按随机数字表法分为观察组与对照组，各组60例。对照组患者第1周给予曲安奈德鼻喷雾剂220 μg，qd，之后减少至110 μg，qd；观察组患者在对照组基础上加服鼻渊通窍颗粒15 g，tid。两组患者均治疗10周。观察两组患者临床疗效及治疗前后白细胞介素（IL）-5，IL-8、鼻黏膜纤毛传输速率（MTR）、鼻腔鼻窦结局测试-20 （SNOT-20）评分、视觉模拟（VAS）评分、Lund-Mackey鼻窦CT评分，并比较不良反应发生率。结果：观察组患者临床总有效率为93.3％，显著高于对照组的85.0％，差异有统计学意义（P＜0.05）。两组患者治疗前IL-5、IL-8、MTR、SNOT-20评分、VAS评分、Lund-Mackey鼻窦CT评分比较，差异均无统计学意义（P＞0.05），两组患者治疗后IL-5、IL-8水平明显降低，MTR则明显提高，SNOT-20评分、VAS评分、Lund-Mackey鼻窦CT评分均明显降低，且观察组显著优于对照组，差异均有统计学意义（P＜0.05）。两组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：鼻渊通窍颗粒联合曲安奈德鼻喷雾剂治疗慢性鼻-鼻窦炎疗效显著，能明显改善患者生活质量，缓解临床症状，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To observe the clinical efficacy and safety of Biyuan tongqiao granule combined with Triamcinolone acetonide spray in the treatment of chronic rhinosinusitis. METHODS： 120 patients with chronic rhinosinusitis were randomly divided into observation group and control group， with 60 cases in each group. Control group was given Triamcinolone acetonide spray 220 μg， qd， in first week， decreasing to 110 μg， qd； observation group was additionally given Biyuan tongqiao granule 15 g， tid， on the basis of control group. Both groups were treated continuously for 10 weeks. The clinical efficacy of 2 groups were observed as well as the levels of MTR， IL-5 and IL-8， SNOT-20 score， VAS score and Lund-Mackey sinus CT score before and after treatment. The incidence of ADR was compared between 2 groups. RESULTS： Total effective rate of observation group was 93.3％， which was significantly higher 85.0％ of control group， with statistical significance （P＜0.05）. There was no statistical significance in IL-5， IL-8， MTR， SNOT-20 score， VAS score and Lund-Mackey sinus CT score between 2 groups before treatment （P＞0.05）. IL-5 and IL-8 levels of 2 groups decreased significantly， while MTR， SNOT-20 score， VAS score and Lund-Mackey sinus CT score were decreased significantly； the observation group was better than the control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Biyuan tongqiao granule combined with Triamcinolone acetonide spray is effective in the treatment of chronic rhinosinusitis， and can effectively improve the quality of life and relieve clinical symptom with good safety. |
| 期刊： | 2016年第27卷第20期 |
| 作者： | 雍军，王咏峰 |
| AUTHORS： | YONG Jun，WANG Yongfeng |
| 关键字： | 鼻渊通窍颗粒；曲安奈德鼻喷雾剂；慢性鼻-鼻窦炎；疗效 |
| KEYWORDS： | Biyuan tongqiao granule； Triamcinolone acetonide spray； Chronic rhinosinusitis； Therapeutic efficacy |
| 阅读数： | 864 次 |
| 本月下载数： | 3 次 |
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