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我院2014－2015年4种抗癫痫药血药浓度监测数据分析
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| 篇名： | 我院2014－2015年4种抗癫痫药血药浓度监测数据分析 |
| TITLE： | |
| 摘要： | 目的：分析4种常用抗癫痫药（AEDs）的血药浓度监测结果，为临床合理用药提供参考。方法：选择我院2014－2015年接受上述4种AEDs：苯妥英钠、卡马西平、丙戊酸钠、奥卡西平血药浓度监测的患者415例，对其血药浓度监测结果进行统计、分析。结果：共监测AEDs血药浓度680次；监测对象以中青年（19～60岁）患者为主，共监测449次（66.03％）；监测结果在有效血药浓度范围内的有360次（52.94％）；361例接受单药治疗的患者中，卡马西平监测结果在有效血药浓度范围内的比例（80.77％）高于其他3种AEDs（苯妥英钠30.00％、丙戊酸钠47.40％、奥卡西平40.38％），差异均有统计学意义（P＜0.05）；54例使用联合治疗的患者中，67.65％的两药联用患者、100％的三药联用患者的监测结果未在其有效血药浓度范围内。结论：我院AEDs血药浓度监测结果总体达标率不高，应加强患者用药教育，提高其依从性，同时结合血药浓度监测结果及临床症状综合评价AEDs的临床疗效，尽量避免联合用药。 |
| ABSTRACT： | OBJECTIVE： To analyze the blood concentration monitoring data of 4 commonly used antiepileptic drugs （AEDs，sodium phenytoin， carbamazepine， sodium valproic acid， oxcarbazepine） in order to provide reference for rational use of drugs in the clinic. METHODS： 415 patients underwent 4 AEDs blood concentration monitoring were selected from our hospital during 2014-2015， and the results of blood concentration monitoring were analyzed statistically. RESULTS： There were 680 cases of AEDs blood concentration monitoring in total. The main objects of serum concentration monitoring were young and middle-aged（range from 19 to 60）， involving 449 cases in total （66.03％）. 360 cases were in the normal range（52.94％）. Among 361 patients receiving single drug therapy， the rates of serum concentration in the normal range were 80.77％ for carbamazepine， which was higher than other 3 AEDs （30.00％ for sodium phenytoin， 47.40％ for sodium valproic acid and 40.38％ for oxcarbazepine）， with statistical significance （P＜0.05）. Among 54 patients receiving combination therapy， the serum concentration monitoring data of 67.65％ patients treated with double-combination therapy and 100％ patients treated with triple-combination therapy deviated from normal range. CONCLUSIONS： The rate of AEDs blood concentration reaching the normal range are in low level in our hospital. It’s necessary to strengthen medication education for patients to improve the compliance of patients； clinical efficacy of AEDs is evaluated on the basis of blood concentration monitoring and clinical symptom， and combination therapy should be avoided as much as possible. |
| 期刊： | 2016年第27卷第20期 |
| 作者： | 陶宏，曹国文，施爱明，鲍君杰 |
| AUTHORS： | TAO Hong，CAO Guowen，SHI Aiming，BAO Junjie |
| 关键字： | 抗癫痫药；血药浓度监测；分析；苯妥英钠；卡马西平；丙戊酸钠；奥卡西平 |
| KEYWORDS： | Antiepileptic drugs； Blood concentration monitoring； Analysis； Sodium phenytoin； Carbamazepine； Sodium valproic acid； Oxcarbazepine |
| 阅读数： | 253 次 |
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