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我院108例化疗致Ⅳ度骨髓抑制的晚期乳腺癌患者用药合理性分析
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| 篇名： | 我院108例化疗致Ⅳ度骨髓抑制的晚期乳腺癌患者用药合理性分析 |
| TITLE： | |
| 摘要： | 目的：为化疗致Ⅳ度骨髓抑制的晚期乳腺癌患者临床合理用药提供参考。方法：采用回顾性分析方法，对某院2014年7月－2015年6月108例化疗致Ⅳ度骨髓抑制的晚期乳腺癌患者的骨髓抑制特点、化疗方案及骨髓抑制对症用药的合理性进行分析。结果：该院晚期乳腺癌患者化疗致Ⅳ度骨髓抑制的发生率为8.3％，主要表现为Ⅳ度粒细胞减少（占94.4％）；发生Ⅳ度骨髓抑制的化疗方案主要为多西他赛+表柔比星、多西他赛、长春瑞滨+洛铂方案。化疗方案不合理主要表现在化疗药物预处理不当（32例，91.4％）；Ⅳ度骨髓抑制处理不合理主要表现在无指征预防使用抗菌药物和抗菌药物选择不当（各29例，各占36.2％）。结论：该院化疗致Ⅳ度骨髓抑制的晚期乳腺癌患者临床用药基本合理，但在化疗药物预处理和Ⅳ度骨髓抑制处理上仍存在部分不合理之处，需进一步改进。 |
| ABSTRACT： | OBJECTIVE： To provide reference for clinical rational drug use in advanced breast cancer patients with grade Ⅳ myelosupression induced by chemotherapy. METHODS： 108 advanced breast cancer patients with grade Ⅳ myelosupression induced by chemotherapy in our hospital from July 2014 to June 2015 were retrospectively analyzed on the characteristics of myelosupression and the reasonability of chemotherapy reguneb and adjuvant drug for myelosupression. RESULTS： The incidence of grade Ⅳ myelosupression induced by chemotherapy in advanced breast cancer patients was 8.3％， chiefly manifesting as grade Ⅳ neutropenia（94.4％）. The chemotherapy regimens which induced grade Ⅳ myelosupression were mainly docetaxel+epirubicin， docetaxel， vinorelbine+lobaplatin； irrational chemotherapy plan mainly shows irrational pretreatment of chemotherapy drug （32 cases， 91.4％）； irrational therapy of myelosupression mainly manifested as rophylactic use of antimicrobials without indication， unsuitable choice of antibiotics （29 cases for each， 36.2％ for each）. CONCLUSIONS： The use of drugs used in advanced breast cancer patients with grade Ⅳ myelosupression induced by chemotherapy is basically rational，yet it is far from perfect in pretreatment of chemotherapy drug and therapy for grade Ⅳ myelosupression， which should be further improved. |
| 期刊： | 2016年第27卷第20期 |
| 作者： | 杜娟，赵秀莉，张文周，王毅刚 |
| AUTHORS： | DU Juan，ZHAO Xiuli，ZHANG Wenzhou，WANG Yigang |
| 关键字： | 化疗；乳腺癌；晚期；Ⅳ度骨髓抑制；合理用药 |
| KEYWORDS： | Chemotherapy； Breast cancer； Advanced； Grade Ⅳ myelosupression； Rational drug use |
| 阅读数： | 343 次 |
| 本月下载数： | 3 次 |
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