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左氧氟沙星与莫西沙星治疗耐药性肺结核的疗效和安全性比较
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| 篇名： | 左氧氟沙星与莫西沙星治疗耐药性肺结核的疗效和安全性比较 |
| TITLE： | |
| 摘要： | 目的：比较左氧氟沙星与莫西沙星治疗耐药性肺结核的疗效和安全性。方法： 148例耐药性肺结核患者随机分为观察组（74例）和对照组（74例）。两组患者均给予氨基水杨酸异烟肼片300 mg+盐酸乙胺丁醇片250 mg+吡嗪酰胺片200 mg+丙硫异烟胺片200 mg，均为每日3次，连用3个月。在此基础上，观察组患者口服盐酸莫西沙星片0.4 g，每日1次；对照组患者口服盐酸左氧氟沙星片0.5 g，每日1次。两组均治疗12个月。比较两组患者的临床疗效，治疗1、4、8、12个月后痰菌转阴率，X线空洞病变改善情况及不良反应发生情况。结果：观察组患者总有效率，治疗1、4、8、12个月后痰菌转阴率，空洞闭合和缩小比例均显著高于对照组，空洞无变化和增大比例及不良反应发生率均显著低于对照组，差异均有统计学意义（P＜0.05）。结论：在常规治疗的基础上，莫西沙星治疗耐药性肺结核的疗效和安全性均优于左氧氟沙星。 |
| ABSTRACT： | OBJECTIVE： To compare the efficacy and safety of levofloxacin and moxifloxacin in the treatment of patients with drug-resistant tuberculosis. METHODS： 148 patients with drug-resistant tuberculosis were divided into observation group（74 cases） and control group（74 cases）. All patients were treated with 300 mg Aminosalicylic acid isoniazid tablet+250 mg Ethambutol hydrochloride tablet+200 mg Pyrazinamide tablet+200 mg Protionamide tablet，3 times a day， treatment for 3 months； based on it， observation group was orally given 0.4 g Moxifloxacin hydrochloride tablet， once a day； control group was orally given 0.5 g Levofloxacin hydrochloride tablet， once a day. They were treated for 12 months. The total efficacy， sputum negative convevsion rate after 1，4，8 and 12 months， X-ray cavities lesion improvement and incidence of ADR in 2 groups were observed. RESULTS： The total efficacy， sputum negative conversion rate after 1， 4， 8 and 12 months， and cavity closure and reduced proportion in observation group were significantly higher than control group， the empty change and increase proportion， incidence of ADR were significantly lower control group， the differences were statistically significant （P＜0.05）. CONCLUSIONS： Based on conventional treatment， moxifloxacin shows better efficacy and safety than levofloxacin in the treatment of patients with drug-resistant tuberculosis. |
| 期刊： | 2016年第27卷第18期 |
| 作者： | 朱刚 |
| AUTHORS： | ZHU Gang |
| 关键字： | 耐药性肺结核；左氧氟沙星；莫西沙星；疗效；安全性 |
| KEYWORDS： | Drug-resistance tuberculosis； Levofloxacin； Moxifloxacin； Efficacy； Safety |
| 阅读数： | 754 次 |
| 本月下载数： | 3 次 |
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