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依达拉奉联合尼莫地平治疗急性大面积脑梗死的临床观察
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| 篇名： | 依达拉奉联合尼莫地平治疗急性大面积脑梗死的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察依达拉奉联合尼莫地平治疗急性大面积脑梗死的疗效和安全性。方法：78例急性大面积脑梗死患者随机分为对照组（38例）和观察组（40例）。对照组患者给予拜阿司匹林、降低颅内压药、维持水电解质平衡药、减轻脑水肿药、注射用血塞通注射液、银杏叶注射液、降脂和降压药、维持血糖药等常规治疗；观察组患者在对照组治疗的基础上给予依达拉奉注射液30 mg，加入0.9％氯化钠注射液100 ml中，静脉滴注（30 min内滴完），每日2次+尼莫地平注射液12 mg，加入0.9％氯化钠注射液500 ml中，静脉滴注，每日1次，滴速0.5～1 mg/h，连用10 d，后改为口服尼莫地片40 mg，每日3次。两组疗程均为15 d。观察两组患者的临床疗效，治疗前后血氧饱和度（SpO2）、血红蛋白（Hb）、总血红蛋白（HbT）、还原血红蛋白（MHb）及不良反应发生情况。结果：观察组患者总有效率显著高于对照组，不良反应发生率显著低于对照组，差异均有统计学意义（P＜0.05）。治疗前，两组患者SpO2、Hb、HbT、MHb比较，差异均无统计学意义（P＞0.05）。治疗后，两组患者SpO2、HbT、MHb均显著高于同组治疗前，且观察组高于对照组，差异均有统计学意义（P＜0.05）；Hb显著低于同组治疗前，差异有统计学意义（P＜0.05），但组间比较差异无统计学意义（P＞0.05）。结论：在常规治疗的基础上，依达拉奉联合尼莫地平治疗急性大面积脑梗死的疗效显著，可有效恢复患者神经功能，保护脑组织，降低不良反应的发生。 |
| ABSTRACT： | OBJECTIVE： To observe the efficacy and safety of edaravone combined with nimodipine in the treatment of acute large area cerebral infarction. METHODS： 78 patients with acute large area cerebral infarction were randomly divided into control group （38 cases） and observation group （40 cases）. Control group received aspirin platelet aggregation， reduced intracranial pressure， maintained water and electrolyte balance， decreased cerebral edema， Xuesetong for injection， Ginkgobiloba injection， lipid and blood pressurelowering， maintained blood sugar and other conventional treatment； observation group additionally received 30 mg Edaravone injection， adding into 100 ml 0.9％ Sodium chloride injection by intravenous infusion （drip completed within 30 min）， twice a day+12 mg Nimodipine injection， adding into 500 ml 0.9％ Sodium chloride injection by intravenous infusion， once a day， with drip rate of 0.5-1 mg/h， for continuous 10 d， then received 40 mg Nimodipine tablet， orally， 3 times a day. The treatment course for both groups was 15 d. Clinical efficacy， blood oxygen saturation （SpO2）， hemoglobin （Hb）， total hemoglobin （HbT）， reduced hemoglobin （MHb） before and after treatment， and the incidence of adverse reactions in 2 groups were observed. RESULTS： The total effective rate in observation group was significantly higher than control group， the incidence of adverse reactions was significantly lower tahn control group， the differences were statistically significant （P＜0.05）. Before treatment， there were no significant differences in SpO2， Hb， HbT and MHb in 2 groups （P＞0.05）. After treatment， the SpO2， HbT and MHb were significantly higher than before， and observation group was higher than control group， the differences were statistically significant （P＜0.05）； Hb was significantly lower than before， the differences were statistically significant （P＜0.05）， but there was no significant difference between 2 groups （P＞0.05）. CONCLUSIONS： Based on the conventional treatment， edaravone combined with nimodipine shows significant efficacy in the treatment of acute large area cerebral infarction， it can effectively recovery neurological function damage and protect the brain tissue， which can reduce the incidence of adverse. |
| 期刊： | 2016年第27卷第18期 |
| 作者： | 郑超，陈奕，张凤，王智超，黄雪琴，石钢 |
| AUTHORS： | ZHENG Chao，CHEN Yi，ZHANG Feng，WANG Zhichao，HUANG Xueqin，SHI Gang |
| 关键字： | 依达拉奉；尼莫地平；急性脑梗死；大面积；疗效；安全性 |
| KEYWORDS： | Edaravone； Nimodipine； Acute cerebral infarction； Large area； Efficacy； Safety |
| 阅读数： | 246 次 |
| 本月下载数： | 2 次 |
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