卡培他滨联合顺铂对晚期胃癌患者疗效及胃癌细胞侵袭转移的影响-中国药房

卡培他滨联合顺铂对晚期胃癌患者疗效及胃癌细胞侵袭转移的影响

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篇名：	卡培他滨联合顺铂对晚期胃癌患者疗效及胃癌细胞侵袭转移的影响
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摘要：	目的：探讨卡培他滨联合顺铂对晚期胃癌患者疗效及胃癌细胞侵袭转移的影响。方法：94例晚期胃癌患者随机分为对照组（47例）和观察组（47例）。对照组患者给予多西紫杉醇注射液65～75 mg/m2，d1，连续静脉滴注2 h+注射用顺铂15～20 mg/m2，d1-5，避光连续静脉滴注2 h。观察组患者给予卡培他滨片1 000 mg/m2，口服，每日2次+注射用顺铂（用法用量同对照组）。两组均以3周为1个周期，共3个周期。观察两组患者的临床疗效，治疗前后的基质金属蛋白酶-2（MMP-2）、MMP-9水平，随访6、12个月生存率及不良反应发生情况。结果：两组患者总有效率比较，差异无统计学意义（P＞0.05）。观察组患者1～2级肝功能异常、血小板下降、恶心呕吐发生率均显著低于对照组，6、12个月生存率均显著高于对照组，差异均有统计学意义（P＜0.05）。治疗前，两组患者MMP-2、MMP-9水平比较，差异均无统计学意义（P＞0.05）。治疗后，两组患者MMP-2、MMP-9水平均显著低于同组治疗前，且观察组低于对照组，差异均有统计学意义（P＜0.05）。结论：卡培他滨联合顺铂治疗晚期胃癌的疗效与多西紫杉醇联合顺铂相当，但在降低MMP-2、MMP-9及安全性方面优于多西紫杉醇联合顺铂。
ABSTRACT：	OBJECTIVE： To observe the efficacy of capecitabine combined with cisplatin in the treatment of advanced gastric cancer and its effect on invasion and metastasis of gastric cancer. METHODS： 94 patients with advanced gastric cancer were randomly divided into control group（47 cases） and observation group（47 cases）. Control group received 65-75 mg/m2 Docetaxel injection， d1， continuous intravenous infusion of 2 h+15-20 mg/m2 Cisplatin for injection， d1-5， continuous intravenous infusion of 2 h in the dark. Observation group received 1 000 mg/m2 Capecitabine tablet， orally， twice a day+Cisplatin for injection（the same usage and dosage with control group）. 3-week was regarded as a treatment course， and it lasted 3 courses. Clinical efficacy， matrix metalloproteinase -2 （MMP-2） and MMP-9 levels were observed， 6 and 12 months survival rate and incidence of adverse reactions were followed-up. RESULTS： There was no significant difference in the total effective rate in 2 groups （P＞0.05）. Grade 1-2 liver dysfunction， thrombocytopenia， and the incidence of nausea and vomiting in observation group were significantly lower than control group， 6 and 12 months survival rates were significantly higher than control group， the differences were statistically significant （P＜0.05）. Before treatment， There was no significant difference in MMP-2 and MMP-9 levels in 2 groups （P＞0.05）. After treatment， MMP-2 and MMP-9 levels in 2 groups were significantly lower than before， and observation group was lower than control group， the differences were statistically significant （P＜0.05）. CONCLUSIONS： The efficacy of capecitabine combined with cisplatin is similar to docetaxel combined with cisplatin in the treatment of advanced gastric cancer， but docetaxel combined with cisplatin is superior in terms of reducing MMP-2 and MMP-9 and safety.
期刊：	2016年第27卷第18期
作者：	李敏，丁祥武
AUTHORS：	LI Min，DING Xiangwu
关键字：	卡培他滨；顺铂；晚期胃癌；疗效；胃癌细胞侵袭转移
KEYWORDS：	Capecitabine； Cisplatin； Advanced gastric cancer； Efficacy； Invasion and metastasis of gastric cancer
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本月下载数：	2 次

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