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黄连上清软胶囊辅助治疗种植体周围炎的临床观察
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| 篇名： | 黄连上清软胶囊辅助治疗种植体周围炎的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察黄连上清软胶囊辅助治疗种植体周围炎的疗效和安全性。方法：40例（种植体72枚）种植体周围炎患者随机分为对照组（20例）和观察组（20例）。对照组患者均行全口龈上洁治术、龈下刮治术、根面平整、调整咬合、松牙固定术或拔除无法保留的患牙，并采用超声洁牙机行洁治术，术后采用3％双氧水、0.9％氯化钠注射液交替冲洗牙周袋，清除残渣，待炎症控制后再行调整磨合；同时给予盐酸米诺环素软膏适量，以精细探针顺牙周袋壁缓慢插入至牙周袋底后，再推入盐酸米诺环素软膏，缓慢后退精细探针使药物溢出至牙龈边缘，30 min内勿漱口及饮水，每周1次。观察组患者在对照组治疗的基础上口服黄连上清软胶囊1.2 g，每日2次。两组均以4周为1个疗程，连续治疗2个疗程。观察两组患者的临床疗效，治疗前后菌斑指数（PLI）、牙周袋深度（PD）、龈沟出血指数（SBI）和白细胞介素1β（IL-1β）、IL-6、IL-2、IL-17水平及不良反应发生情况。结果：观察组患者总有效率显著高于对照组，差异有统计学意义（P＜0.05）。治疗后，两组患者PLI、PD、SBI、IL-1β、IL-6、IL-2、IL-17水平均显著低于同组治疗前，且观察组低于对照组，差异均有统计学意义（P＜0.05）。观察组患者不良反应发生率高于对照组，差异有统计学意义（P＜0.05），但症状均较轻微。结论：在常规牙周治疗的基础上，黄连上清软胶囊辅助治疗种植体周围炎的疗效显著，可降低患者龈沟液中炎症因子水平，但不良反应较多。 |
| ABSTRACT： | OBJECTIVE： To observe the efficacy and safety of Huanglian shangqing soft capsule in the adjuvant treatment of inflammation around the implant. METHODS： 40 patients （72 implants） with inflammation around the implant were randomly divided into control group （20 cases） and observation group （20 cases）. Control group received full mouth supragingival scaling technique， subgingival curettage， root planing， occlusal adjustment， loose teeth fixation or removal can not be reserved teeth using ultrasonic scaler row scaling postoperative with 3％ hydrogen peroxide， 0.9％ Sodium chloride injection alternately flushing periodontal pocket， removing residue until the inflammation control after the break-adjusted+appropriate amount of Minocycline hydrochloride ointment， along with fine needles inserted into the periodontal pocket wall slowly until bag after pushed into the bottom of Minocycline hydrochloride ointment， slow retreated the drug overflow until the gingival margin， no gargle and drinking water within half an hour， once a week. Observation group additionally received 1.2 g Huanglian shangqing soft capsules， twice a day. 4-week was regarded as 1 course， and it last 2 courses. Clinical efficacy， PLI， PD， SBI，IL-1β， IL-6， IL-2 and IL-17 levels before and after treatment， and the incidence of adverse reactions in 2 groups were observed. RESULTS： The total effective rate in observation group was significantly higher than control group， the difference was statistically significant （P＜0.05）. After treatment， the PLI， PD， SBI， IL-1β， IL-6， IL-2 and IL-17 levels in 2 groups were significantly lower than before， and observation group was lower than control group， the differences were statistically significant （P＜0.05）. The incidence of adverse reactions in observation group was significantly higher than control group， the difference was statistically significant （P＜0.05）， but the symptoms were mild. CONCLUSIONS： Based on conventional treatment， Huanglian shangqing soft capsule shows significant efficacy in the adjuvant treatment of inflammation around the implant， it can reduce inflammatory cytokine levels in gingival sulcus fluid， but with more adverse reactions. |
| 期刊： | 2016年第27卷第18期 |
| 作者： | 黄涛，刘琳 |
| AUTHORS： | HUANG Tao，LIU Lin |
| 关键字： | 黄连上清软胶囊；种植体周围炎；牙周基础治疗 |
| KEYWORDS： | Huanglian shangqing soft capsule； Inflammation around the implant； Periodontal basic treatment |
| 阅读数： | 434 次 |
| 本月下载数： | 2 次 |
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