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西酞普兰治疗肺癌术后抑郁症的临床观察
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| 篇名： | 西酞普兰治疗肺癌术后抑郁症的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察西酞普兰治疗肺癌术后抑郁症的临床疗效及安全性。方法：选取肺癌术后伴发抑郁症的患者114例，按随机数字表法分为观察组和对照组，各57例。对照组患者术后给予营养支持、平衡电解质等常规治疗，未服用抗抑郁药物；观察组患者术后口服氢溴酸西酞普兰片20 mg，qd。两组患者均连续治疗6周。观察两组患者临床疗效及治疗前后汉密尔顿抑郁量表（HAMD）评分、汉密尔顿焦虑量表（HAMA）评分、健康调查量表（SF-36）评分，并记录不良反应发生情况。结果：观察组总有效率为87.72％，显著高于对照组的71.93％，差异有统计学意义（P＜0.05）；两组患者治疗前HAMD评分、HAMA评分及SF-36各项评分和总分比较，差异无统计学意义（P＞0.05）；两组患者治疗后HAMA评分、HAMD评分显著降低，且观察组显著低于对照组，SF-36各项评分和总分显著升高，且观察组显著高于对照组，差异均有统计学意义（P＜0.05）。两组患者均未见明显不良反应发生。结论：西酞普兰治疗肺癌术后抑郁症的疗效显著，能明显改善患者精神状态和生存质量，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To observe clinical efficacy and safety of citalopram in the treatment of depression patients after lung cancer operation. METHODS： 114 depression patients after lung cancer operation were selected and randomly divided into observation group and control group （n＝57）. Control group was given routine treatment as nutrition support and electrolyte balance， but had no anti-depression drugs； observation group was given Citalopram tablet 20 mg orally， qd. Two groups were treated for 6 weeks. Clinical efficacy， HAMD and HAMA scores， each score and total score of SF-36 were observed before and after treatment. The occurrence of ADR was recorded. RESULTS： The total effective rate of observation group was 87.72％， which was significantly higher than that that of control group （71.93％）， with statistical significance （P＜0.05）； there was no statistical significance in HAMA score， HAMD score， each score and total score of SF-36 between 2 groups before treatment （P＞0.05）； HAMA score and HAMD score of 2 groups decreased significantly after treatment， the observation group was lower than the control group； each score and total score of SF-36 increased significantly， the observation group was higher than the control group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： Citalopram is effective and safe for depression after lung cancer operation， can improve mental state and quality of life. |
| 期刊： | 2016年第27卷第17期 |
| 作者： | 孙振卿，郭强，李鹤飞，王海波，祖金池，石林，张越，李亚静，桑文华 |
| AUTHORS： | SUN Zhenqing，GUO Qiang，LI Hefei，WANG Haibo，ZU Jinchi，SHI Lin，ZHANG Yue，LI Yajing，SANG Wenhua |
| 关键字： | 西酞普兰；抑郁症；安全性；肺癌 |
| KEYWORDS： | Citalopram； Depression； Safety； Lung cancer |
| 阅读数： | 322 次 |
| 本月下载数： | 2 次 |
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