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滋肾健脾活血汤联合消心痛胶囊治疗2型糖尿病合并无痛性心肌缺血的临床观察
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| 篇名： | 滋肾健脾活血汤联合消心痛胶囊治疗2型糖尿病合并无痛性心肌缺血的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察滋肾健脾活血汤联合消心痛胶囊治疗2型糖尿病合并无痛性心肌缺血（SMI）的临床疗效及安全性。方法：选择2型糖尿病合并SMI患者126例，按随机数字表法分为对照组（62例）和观察组（64例）。两组患者均给予饮食指导，服用磺脲类、双胍类降血糖药物。对照组患者口服消心痛胶囊10 mg，tid；观察组患者在对照组基础上加服滋肾健脾活血汤400～500 ml，bid。两组患者均治疗7 d。观察两组患者中医胸痹症状疗效、冠脉支脉狭窄改善情况及心电图ST段低压出线次数和持续时间，并比较不良反应发生情况。结果：观察组的中医胸痹症状疗效以及冠状动脉支脉狭窄改善情况均显著优于对照组，差异有统计学意义（P＜0.05）；观察组患者心电图ST波低压出线次数及持续时间显著少于或短于对照组，差异有统计学意义（P＜0.05）。两组患者均未见明显不良反应发生。结论：滋肾健脾活血汤联合消心痛胶囊治疗2型糖尿病合并SMI疗效显著，能明显改善患者中医胸痹症状、冠状动脉支脉狭窄及心电图，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To observe clinical efficacy and safety of Zishen jianpi huoxue decoction combined with Xiaoxintong capsule in the treatment of type 2 diabetes complicating with silent myocardial ischemia （SMI）. METHODS： 126 patients with type 2 diabetes complicating with SMI were selected and randomly divided into control group （62 case） and observation group （64 cases）. Both group were given diet guidance and hypoglycemic drugs as sulfonylureas， biguanides. Control group was given Xiaoxintong capsule 10 mg， tid； observation group was additionally given Zishen jianpi huoxue decoction 400-500 ml， bid. Both groups received ?treatment for 7 d. Therapeutic efficacy of thoracic obstruction， improvement of coronary artery branch stenosis and times and duration of electrocardiogram ST segment low voltage outlet were observed in 2 groups. ADR was compared between 2 groups. RESULTS： Therapeutic efficacy of thoracic obstruction and improvement of coronary artery branch stenosis in observation group were significantly better than in control group， with statistical significance （P＜0.05）； the times and duration of electrocardiogram ST segment low voltage outlet in observation group were significantly lesser shorter ?than in control group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： Zishen jianpi huoxue decoction complicating with Xiaoxintong capsule shows significantly therapeutic efficacy in the treatment of type 2 diabetes complicating with SMI with good safety. |
| 期刊： | 2016年第27卷第17期 |
| 作者： | 谢丽华，郑航 |
| AUTHORS： | XIE Lihua1，ZHENG Hang |
| 关键字： | 滋肾健脾活血汤；消心痛胶囊；2型糖尿病；无痛性心肌缺血 |
| KEYWORDS： | Zishen jianpi huoxue decoction； Xiaoxintong capsule； Type 2 diabetes； Silent myocardial ischemia |
| 阅读数： | 280 次 |
| 本月下载数： | 1 次 |
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