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布地奈德与丙酸倍氯米松辅助特布他林雾化吸入治疗小儿哮喘急性发作的对比研究
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| 篇名： | 布地奈德与丙酸倍氯米松辅助特布他林雾化吸入治疗小儿哮喘急性发作的对比研究 |
| TITLE： | |
| 摘要： | 目的：比较布地奈德与丙酸倍氯米松辅助特布他林雾化吸入治疗小儿哮喘急性发作的临床疗效及安全性。方法：150例小儿哮喘急性发作患儿按随机区组法分为A组和B组，各75例。两组患儿均给予包括低流量吸氧、祛痰、止咳、扩张支气管及抗感染等对症支持治疗，并雾化吸入特布他林，每次1 ml，bid；在此基础上，A组患儿辅助使用布地奈德雾化吸入，每次2 ml，bid；B组患儿辅助使用丙酸倍氯米松雾化吸入，每次2 ml，bid。两组疗程均为7 d。观察两组患儿的临床疗效、哮喘控制情况、呼气流量峰值占预计值的百分比（PEF％）和不良反应发生情况，记录患儿症状体征消失时间和住院时间，并对患儿治疗前1 d和治疗后7 d的症状体征进行评分。结果：治疗过程中，A、B组分别脱落2、3例患儿。A、B组患儿的总有效率分别为91.78％、94.44％，哮喘控制率分别为95.89％、94.44％，组间比较差异均无统计学意义（P＞0.05）；A组患儿的呼吸困难消失时间、咳嗽消失时间、肺部哮鸣音消失时间及住院时间分别为（2.11±0.54）、（3.28±0.93）、（4.38±1.05）、（5.83±1.29）d，B组患儿分别为（2.07±0.52）、（3.30±0.96）、（4.45±1.08）、（5.90±1.33）d，组间比较差异均无统计学意义（P＞0.05）。A组患儿治疗前后的症状体征评分分别为（4.28±0.94）、（0.15±0.04）分，B组患儿分别为（4.23±0.91）、（0.11±0.03）分，组内比较差异均有统计学意义（P＜0.05），但组间比较差异均无统计学意义（P＞0.05）。A组患儿治疗前后的PEF％分别为（51.4±9.8）％、（67.2±11.2）％，B组患儿治疗前后的PEF％分别为（52.0±7.1）％、（68.3±8.7）％，组内比较差异均有统计学意义（P＜0.05），但组间比较差异均无统计学意义（P＞0.05）。两组患儿均未见明显不良反应发生。结论：布地奈德与丙酸倍氯米松辅助特布他林雾化吸入治疗小儿哮喘急性发作效果接近，均可有效缓解患儿的症状体征，提高哮喘控制率，缩短康复时间，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To compare clinical efficacy and safety of budesonide and beclometasone assisting with terbutaline by atomization inhalation in the treatment of acute pediatric asthma attack. METHODS： 150 pediatric patients with acute asthma attack were randomly divided into group A and group B， with 75 cases in each group. Both group received symptomatic support treatment as low-flow oxygen inhalation， eliminating phlegm， relieving a cough， dilating bronchus and anti-infection， and atomization inhalation of ?budesonide， 1 ml each time， bid. Based on this， group A was given atomization inhalation of budesonide， 2 ml each time， bid； group B was given atomization inhalation of beclometasone， 2 ml， bid. Treatment course of 2 groups lasted for 7 d. Clinical efficacy， asthma control，PEF％ and the occurrence of ADR were observed in 2 groups； the time of symptoms and signs disappearance and hospitalization time were recorded， and symptoms and signs of children were scored 1 day before treatment and 7 days after treatment. RESULTS： During treatment， 2 cases and 3 cases were withdraw from the test in group A and group B， respectively. The total effective rates of group A and B were 91.78％ and 94.44％， and the rate of asthma control 95.89％ and 94.44％， without statistical significance （P＞0.05）. The time of breathing difficulties disappearance， cough disappearance time， wheezing disappearance time and hospitalization time of group A were separately （2.11±0.54）， （3.28±0.93）， （4.38±1.05）， （5.83±1.29）d； those of B group were separately （2.07±0.52），（3.30±0.96）， （4.45±1.08）， （5.90±1.33）d， there was no significant difference between 2 groups（P＞0.05）. The clinical symptoms and signs score of group A before and after treatment were separately （4.28±0.94） and （0.15±0.04）； those of before and after treatment of group B were separately （4.23±0.91） and （0.11±0.03）. There was significant difference before and after treatment （P＜0.05）， but there was no significant difference between 2 groups （P＞0.05）. The PEF％ of group A before and after treatment were separately （51.4±9.8）％ and （67.2±11.2）％； those of before and after treatment of group B were separately （52.0±7.1）％ and （68.3±8.7）％. There was significant difference before and after treatment （P＜0.05）， but there was no significant difference between 2 groups （P＞0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： Budesonide and beclometasone assisting with terbutaline by atomization inhalation in the treatment for acute pediatric asthma attack possess the same effects and can efficiently relieve symptoms and signs， increase the rate of asthma control and shorten the rehabilitation course with good safety. |
| 期刊： | 2016年第27卷第17期 |
| 作者： | 邹艳萍，罗小兰，刘利 |
| AUTHORS： | ZOU Yanping，LUO Xiaolan，LIU Li |
| 关键字： | 布地奈德；丙酸倍氯米松；特布他林；小儿哮喘；急性发作；雾化吸入 |
| KEYWORDS： | Budesonide； Beclometasone； Terbutaline； Pediatric asthma； Acute attack； Atomization inhalation |
| 阅读数： | 766 次 |
| 本月下载数： | 5 次 |
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