丹参川芎嗪注射液联合盐酸氟桂利嗪预防下肢骨折术后长期卧床患者阵发性位置性眩晕及下肢深静脉血栓的临床观察-中国药房

丹参川芎嗪注射液联合盐酸氟桂利嗪预防下肢骨折术后长期卧床患者阵发性位置性眩晕及下肢深静脉血栓的临床观察

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篇名：	丹参川芎嗪注射液联合盐酸氟桂利嗪预防下肢骨折术后长期卧床患者阵发性位置性眩晕及下肢深静脉血栓的临床观察
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摘要：	目的：观察丹参川芎嗪注射液联合盐酸氟桂利嗪预防下肢骨折术后长期卧床患者阵发性位置性眩晕（BPPV）及下肢深静脉血栓（DVT）的疗效及安全性。方法：选取下肢骨折术后长期卧床静养患者300例，按随机数字表法分为观察组和对照组，各150例。对照组患者口服盐酸氟桂利嗪胶囊10 mg，qd；观察组患者在对照组基础上加用丹参川芎嗪注射液10 ml+5％葡萄糖注射液250 ml，ivgtt，qd。两组患者均治疗2周。观察两组患者干预后BPPV、DVT发生率及干预前后下肢周径、凝血指标、血液流变学指标和炎症因子水平，并比较不良反应发生率。结果：观察组患者干预后BPPV、DVT发生率分别为18.0％和16.7％，显著低于对照组的48.7％和52.7％，差异有统计学意义（P＜0.05）；两组患者干预后下肢周径、各血液流变学指标及炎症因子水平均显著降低，凝血指标显著升高，且观察组显著优于对照组，差异有统计学意义（P＜0.05）。两组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：丹参川芎嗪注射液联合盐酸氟桂利嗪预防下肢骨折长期卧床患者BPPV、DVT疗效显著，且不良反应发生率较低。
ABSTRACT：	OBJECTIVE： To observe therapeutic efficacy and safety of Danshen chuanxiongqin injection combined with flunarizine hydrochloride in the benign prevention and treatment of paroxysmal positional vertigo （BPPV） and lower extremity deep venous thrombosis （DVT） in post-operative long-term bedridden patients with lower limb fractures. METHODS： 300 post-operative long-term bedridden patients with lower limb fractures were selected and randomly divided into observation group and control group， with 150 cases in each group. Control group was given Flunarizine hydrochloride capsules orally 10 mg， qd； observation group was additionally given Danshen chuanxiongqin injection 10 ml+5％ Glucose injection 250 ml， ivgtt， qd. The incidence of BPPV and DVT were observed in 2 groups after intervention， and the circumference of lower limb， blood coagulation indexes， blood rheology indexes and inflammatory factor were observed before and after intervention， and the incidence of ADR was compared. RESULTS： The incidence of BPPV and DVT in observation group were 18.0％ and 16.7％， which were significantly lower than in control group （48.7％ and 52.7％）， with statistical significance （P＜0.05）； after intervention， the circumference of lower limb， blood rheology indexes and the levels of inflammatory factors in 2 groups were decreased significantly， ?while the coagulation indicators were significantly improved； the observation group was better than the control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Danshen chuanxiongqin injection combined with flunarizine hydrochloride is effective in the prevention of BPPV and DVT in long-term bedridden patients with lower limb fractures， with low incidence of ADR.
期刊：	2016年第27卷第17期
作者：	陈贞君，方嘉阳，邱星颖，沈丰丰，傅祥浈，戢婷，李华
AUTHORS：	CHEN Zhenjun，FANG Jiayang，QIU Xingying，SHEN Fengfeng，FU Xiangzhen，JI Ting，LI Hua
关键字：	丹参川芎嗪注射液；盐酸氟桂利嗪；下肢骨折；长期卧床；阵发性位置性眩晕；下肢深静脉血栓
KEYWORDS：	Danshen chuanxiongqin injection； Flumarizine hydrochloride； Lower limb fractures； Long-term bedridden； Paroxysmal positional vertigo； Lower extremity deep venous thrombosis
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