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骨化三醇对慢性肾功能衰竭患者相关指标的影响
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| 篇名： | 骨化三醇对慢性肾功能衰竭患者相关指标的影响 |
| TITLE： | |
| 摘要： | 目的：探讨骨化三醇对慢性肾功能衰竭患者相关指标的影响。方法： 114例慢肾衰患者随机分为对照组（57例）和观察组（57例）。对照组患者给予优质低蛋白质饮食、低磷饮食，必要时给予磷结合剂、碳酸钙D3片等常规治疗；观察组患者在对照组治疗的基础上给予骨化三醇胶丸0.25 μg，口服，每日1次。两组疗程均为8周。观察两组患者治疗前后血清炎症因子、碱性磷酸酶、血红蛋白、红细胞、血肌酐、尿素氮水平及不良反应发生情况。结果：治疗前，两组患者血清炎症因子、碱性磷酸酶、血红蛋白、红细胞、血肌酐、尿素氮水平，差异均无统计学意义（P＞0.05）。治疗后，两组患者血清炎症因子、碱性磷酸酶、血肌酐、尿素氮水平均显著低于同组治疗前，且观察组低于对照组，差异均有统计学意义（P＜0.05）；两组患者血红蛋白、红细胞水平治疗前后比较，差异均无统计学意义（P＞0.05）。两组患者治疗期间均未见明显不良反应发生。 结论：在常规治疗的基础上，骨化三醇可降低慢性肾功能衰竭患者血清炎症因子水平，改善微炎症状态及肾功能。 |
| ABSTRACT： | OBJECTIVE： To investigate the effects of calcitriol on related indicators in patients with chronic renal failure （CRF）. METHODS： 114 patients with CRF were randomly divided into observation group （57 cases） and control group （57 cases）. Control group was given high-quality low-protein and low phosphorus diet， if necessary， phosphate binders， Calcium D3 tablet and other conventional treatment； observation group was additionally given 0.25 μg Calcitriol soft capsule， once a day. The treatment course for both groups was 8 weeks. Serum levels of inflammatory factors， alkaline phosphatase， hemoglobin， erythrocyte， serum creatinine and urea nitrogen levels and adverse reactions in 2 groups before and after treatment were observed. RESULTS： Before treatment，there were no significant differences in the serum levels of inflammatory factors，alkaline phosphatase，hemoglobin，erythrocyte，senum creatininine and ureanitrogen between 2 groups（P＞0.05）. After treatment， serum inflammatory factors， alkaline phosphatase， serum creatinine and urea nitrogen levels in 2 groups were significantly shorter than before， and observation group was lower than control group， the differences were statistically significant （P＜0.05）； there were no significant differences in the hemoglobin and erythrocyte levels before and after treatment between 2 groups（P＞0.05）. And there was no obvious adverse reactions between 2 groups during treatment. CONCLUSIONS： Based on the conventional treatment， calcitriol can reduce the levels of serum inflammatory factors and improve micro-inflammatory state and renal function in patients with CRF. |
| 期刊： | 2016年第27卷第15期 |
| 作者： | 陆建中，陶兰，徐星娥，吴晓芬，王海燕 |
| AUTHORS： | LU Jianzhong，TAO Lan，XU Xing’e，WU Xiaofen，WANG Haiyan |
| 关键字： | 骨化三醇；慢性肾功能衰竭；微炎症状态；血红蛋白；碱性磷酸酶；红细胞；肾功能 |
| KEYWORDS： | Calcitriol； Chronic renal failure； Micro-inflammatory state； Hemoglobin； Alkaline phosphatase； erythrocyte； Renal function |
| 阅读数： | 428 次 |
| 本月下载数： | 1 次 |
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