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中药材一测多评中相对校正因子的规律性文献调查和分析
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| 篇名： | 中药材一测多评中相对校正因子的规律性文献调查和分析 |
| TITLE： | |
| 摘要： | 目的：探寻相对校正因子（RCF）在中药材一测多评中应用的规律性。方法：以中国知网（CNKI）文献数据库为来源，采用文献检索方法收集大量有关中药材一测多评的文献，提取文献中通过一测多评法（QAMS）所得含量的计算值与外标法所得含量的实测值，并通过SPSS 19.0软件计算其计算值与实测值间相对标准偏差的百分值（RSD，％），绘制散点图分析RSD与RCF的相关性。结果：RCF值在＞0.62～1.53区间分布较多，占全部数据的76.7％，且在此区间时，计算值与实测值的相似度较大，而RSD＜3.0％的数据占此区间全部数据的88.8％，可信度较好。与此同时，计算值与实测值的相似程度还受到其他待测成分与内参物之间母核结构和理化性质差异的影响，母核结构相似时，计算值与实测值的相似度较大；母核结构差异大时，计算值与实测值的相似度较小；而母核结构相似、理化性质差异大时，计算值与实测值的相似度也较小。结论：QAMS法中RCF会影响中药材待测成分含量测定结果的可信度，有必要建立中药材多成分QAMS法测定中RCF、RSD等相关参数数据库。 |
| ABSTRACT： | OBJECTIVE： To explore the regularity of relative correction factor （RCF） in multi-components by single marker （QAMS）. METHODS： With the source of CNKI， literature retrieval was used to collect the relevant documents of multi-components by single marker （QAMS） and extract the calculated values by quantitative analysis of multi-components by single marker QAMS and measured values by external standard method （ESM）， SPSS 19.0 software was used to calculate the percentage value （RSD， ％） of relative standard deviation between calculated values and measured values， and the correlation between RSD and RCF was analyzed by drawing a scatter plot. RESULTS： Most of RCF values distributed in the range of ＞0.62-1.53， accounting for 76.7％ to all data. Calculated values and measured values showed high similarity in this range and the RSD＜3.0％ data accounted for 88.8％ to all data， which had good credibility. Meanwhile， the similarity of calculated values and measured values was influenced by the differences of structure and physicochemical property of parent nucleus between other components under measured and internal references. The high degree of similarity between calculated values and measured values were decisive by very similar structures of parent nucleus； the low degree was decisive by discrepant structures； and the low degree was also decisive by very similar structures and discrepant physicochemical property of parent nucleus. CONCLUSIONS： RCF will affect the credibility of content determination results for components under measured in QAMS， it is necessary to establish database of RCF， RSD and related parameters. |
| 期刊： | 2016年第27卷第15期 |
| 作者： | 吕邵娃，于风明，苏红，郭玉岩，孙爽，匡海学 |
| AUTHORS： | LYU Shaowa，YU Fengming，SU Hong，GUO Yuyan，SUN Shuang，KUANG Haixue |
| 关键字： | 中药材；含量测定；一测多评法；相对校正因子；相对标准偏差 |
| KEYWORDS： | Chinese herbal medicine； Content determination； Quantitative analysis of multi-components by a single marker； Relative correction factor； Relative standard deviation |
| 阅读数： | 948 次 |
| 本月下载数： | 8 次 |
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