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生化汤加减联合抗菌药物治疗血瘀型产后发热的临床观察
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| 篇名： | 生化汤加减联合抗菌药物治疗血瘀型产后发热的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察生化汤加减联合抗菌药物治疗血瘀型产后发热的临床疗效及安全性。方法：178例血瘀型产后发热患者按照随机数字表法分为观察组和对照组，各89例。对照组患者给予物理降温、补液等基础治疗，并根据细菌培养结果采用合适的抗菌药物；观察组患者在对照组治疗基础上加用生化汤加减，每日1剂，以水煎成300 ml，分早晚2次服用。两组疗程均为5 d。比较两组患者的临床疗效、治疗前后白细胞计数、体温降至正常例数和实验室检查指标，并观察不良反应发生情况。结果：观察组患者的总有效率（94.38％）显著高于对照组（82.02％），差异有统计学意义（P＜0.05）；两组患者治疗1、3、5 d后的白细胞计数均较治疗前显著下降，且观察组下降幅度显著大于对照组同期，差异有统计学意义（P＜0.05）；两组患者治疗1、3、5 d后的体温降至正常例数组内比较，差异均有统计学意义（P＜0.05），且观察组体温降至正常例数显著多于对照组同期，差异有统计学意义（P＜0.05）；两组患者治疗后的血浆黏度、红细胞沉降率、纤维蛋白原水平均较治疗前显著下降，且观察组显著低于对照组，差异均有统计学意义（P＜0.05）。两组患者治疗期间均未见明显不良反应。结论：生化汤加减治疗可明显提高对血瘀型产后发热的疗效，且安全性良好。 |
| ABSTRACT： | OBJECTIVE： To observe clinical efficacy and safety of Jiajian shenghua decoction combined with antibiotics in the treatment of blood-stasis type postpartum fever. METHODS： 178 patients with blood-stasis type postpartum fever were randomized into observation group and control group， with 89 cases in each group. Control group received basic treatment as physical cooling， fluid infusion， and adopt suitable antibiotics according to the results of bacterial culture test； observation group was additionally given Jiajian shenghua decoction， one dose a day， decocting 300 ml with water， day and night at twice. Treatment course of 2 groups lasted for 5 d. Clinical efficacy was compared between 2 groups， and white blood cell count， case number of body temperature returned to normal and lab indexes were observed before and after treatment. The occurrence of ADR was also observed. RESULTS： The overall response rate （94.38％） of observation group was significantly higher that （82.02％） of control group， with statistical significance （P＜0.05）； 1 d， 3 d， 5 d after treatment， white blood cell count of 2 groups decreased significantly compared to before treatment， the observation group was more significant than control group， with statistical significance （P＜0.05）； there was statistical significance in the case number of body temperature returned to normal between 2 groups 1 d， 3 d， 5 d after treatment， with statistical significance （P＜0.05）； the observation group was more than control group， with statistical significance （P＜0.05）. The plasma viscosity， erythrocyte sedimentation rate， fibrinogen of 2 groups decreased significantly after treatment， compared to before treatment， and the observation group was significantly lower than control group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups during treatment. CONCLUSIONS： Jiajian Shenghua decoction can increase the effect and has good safety for blood-stasis type postpartum fever. |
| 期刊： | 2016年第27卷第14期 |
| 作者： | 印贤琴，侯俐，沈娅 |
| AUTHORS： | YIN Xianqin，HOU Li，SHEN Ya |
| 关键字： | 生化汤加减；抗菌药物；血瘀型产后发热；临床疗效；安全性 |
| KEYWORDS： | Jiajian shenghua decoction； Antibiotics； Blood-stasis type postpartum fever； Clinical efficacy； Safety |
| 阅读数： | 232 次 |
| 本月下载数： | 2 次 |
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