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尼可地尔联合阿托伐他汀治疗不稳定型心绞痛的临床观察
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| 篇名： | 尼可地尔联合阿托伐他汀治疗不稳定型心绞痛的临床观察 |
| TITLE： | |
| 摘要： | 目的： 观察尼可地尔联合阿托伐他汀治疗不稳定型心绞痛的临床疗效及安全性。方法：选取不稳定型心绞痛患者60例，按随机数字表法分为观察组和对照组，各30例。对照组患者给予单硝酸异山梨酯片40 mg，qd；观察组患者给予尼可地尔片5 mg联合阿托伐他汀钙片10 mg，tid。两组患者均连续治疗1个月。观察两组患者临床疗效及治疗前后心电图T波倒置与ST段抬高的发生率，并记录不良反应。结果：观察组患者临床有效率为93.33％，显著高于对照组的16.67％，差异有统计学意义（P＜0.05）。治疗前，两组患者心电图T波倒置与ST段升高发生率比较，差异无统计学意义（P＞0.05）；治疗后，观察组患者T波倒置与ST段升高发生率显著低于对照组，差异有统计学意义（P＜0.05）。观察组患者头痛、皮疹、食欲不振发生率均显著低于对照组，差异有统计学意义（P＜0.05）；腹泻、颜面潮红发生率与对照组比较，差异无统计学意义（P＞0.05）。结论：尼可地尔联合阿托伐他汀治疗不稳定型心绞痛较单硝酸异山梨酯疗效显著，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To observe the clinical efficacy and safety of nicorandil combined with atorvastatin in the treatment of unstable angina pectoris. METHODS： 60 patients with unstable angina pectoris were selected and randomly divided into observation group and control group with 30 cases in each group. Control group was given isosorbide 5-mononitrate 40 mg， qd； observation group was given nicorandil 5 mg combined with atorvastatin 10 mg， tid. Both group were treated for consecutive one month. Clinical efficacy was observed in 2 groups and the incidence of electrocardiogram T wave inversion and ST segment elevation were also observed before and after treatment， and ADR was recorded. RESULTS： The effective rate of observation group was 93.33％， which was significantly higher than 16.67％ of control group， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in the incidence of electrocardiogram T wave inversion and ST segment elevation between 2 groups （P＞0.05）； after treatment， the incidence of electrocardiogram T wave inversion and ST segment elevation in observation group was significantly lower than in control group， with statistical significance （P＜0.05）. The incidence of headache， rash， loss of appetite in observation group were significantly lower than in control group， with statistical significance （P＜0.05）， and there was no statistical significance in the incidence of diarrhea and facial blushing between 2 groups （P＞0.05）. CONCLUSIONS： Nicorandil combined with atorvastatin shows better therapeutic efficacy and good safety than isosorbide mononitrate in the treatment of unstable angina pectoris. |
| 期刊： | 2016年第27卷第14期 |
| 作者： | 牟丽娜，陆芳，韩世飞 |
| AUTHORS： | MOU Lina，LU Fang，HAN Shifei |
| 关键字： | 尼可地尔；阿托伐他汀；不稳定型心绞痛；疗效；心电图；安全性 |
| KEYWORDS： | Nicorandil； Atorvastatin； Unstable angina pectoris； Clinical efficacy； Electrocardiogram； Safety |
| 阅读数： | 972 次 |
| 本月下载数： | 4 次 |
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