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红花黄色素联合尤瑞克林治疗急性脑梗死的临床观察
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| 篇名： | 红花黄色素联合尤瑞克林治疗急性脑梗死的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察红花黄色素联合尤瑞克林治疗急性脑梗死的临床疗效及安全性。方法：将170例急性脑梗死患者，按随机数字表法分为观察组和对照组，各85例。两组患者均接受降压、调脂、控制血糖、纠正电解质紊乱、营养保护神经、降颅内压等常规治疗。对照组患者在常规治疗基础上给予红花黄色素注射液100 mg加入0.9％氯化钠注射液250 ml中，ivgtt，qd；观察组患者在对照组基础上加用尤瑞克林注射液0.15 PNA单位加入0.9％氯化钠注射液250 ml中，ivgtt，qd。两组患者均治疗2周。观察两组患者临床疗效，采用美国国立卫生研究院卒中量表（NIHSS）评分、改良RANKIN量表（MRS）评分评价神经功能缺损程度和残障程度，并比较两组患者治疗前后血常规、凝血四项、肝肾功能水平。结果：观察组患者总有效率为90.6％，显著高于对照组的63.5％，差异有统计学意义（P＜0.05）。治疗后，两组患者NIHSS、MRS评分均显著降低，且观察组显著低于对照组，差异有统计学意义（P＜0.05）。两组患者治疗前后血常规、凝血四项、肝功能、肾功能比较，差异无统计学意义（P＞0.05）。结论：红花黄色素联合尤瑞克林治疗急性脑梗死疗效显著，能明显改善患者的神经功能缺损程度和残障程度，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To observe clinical efficacy and safety of carthamin yellow pigment combined with urinary kallidinogenase in the treatment of acute cerebral infarction. METHODS： 170 patients with acute cerebral infarction were randomly divided into observation group and control group with 85 cases in each group. Both groups received routine treatment of reducing blood pressure， regulating blood lipid， controlling blood glucose， correcting electrolyte disturbances， nourishing and protecting nerve， reducing intracranial pressure， etc. Control group was additionally given Carthamin yellow pigment injection 100 mg added into 250 ml 0.9％ Sodium chloride injection， ivgtt， qd； observation group was additionally given Urinary kallidinogenase injection 0.15 PNA added into 250 ml 0.9％ Sodium chloride injection， ivgtt， qd， on the basis of control group. Both groups received 2 courses of treatment. Clinical efficacy of 2 groups was observed in 2 groups， and NIHSS and MRS were also observed before and after treatment evalnation of neurological deficits and disability； blood routine， 4 blood coagulation items， hepatic and liver function were compared between 2 groups before and after treatment. RESULTS： Total effective rate of observation group was 90.6％， which was significantly higher than 63.5％ of control group， with statistical significance （P＜0.05）. After treatment， NIHSS and MRS of 2 groups decreased significantly， and the observation group was lower than the control group， with statistical significance （P＜0.05）. There was no statistical significance in blood routine， 4 blood coagulation items， hepatic and liver function between 2 groups before and after treatment （P＞0.05）. No erythra and electrocardiographic abnormality and other ADRs was observed in 2 groups. CONCLUSIONS： Carthamin yellow pigment combined with urinary kallidinogenase shows obvious therapeutic efficacy and good safety in the treatment of acute cerebral infarction improve the degree of neurological deficits and the degree of disability. |
| 期刊： | 2016年第27卷第14期 |
| 作者： | 王昕，刘军，邵芳，陈明巧，熊建勋 |
| AUTHORS： | WANG Xin，LIU Jun，SHAO Fang，CHEN Mingqiao，XIONG Jianxun |
| 关键字： | 红花黄色素；尤瑞克林；急性脑梗死；疗效；安全性 |
| KEYWORDS： | Carthamin yellow pigment； Urinary kallidinogenase； Acute cerebral infarction； Clinical efficacy； Safety |
| 阅读数： | 224 次 |
| 本月下载数： | 3 次 |
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