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麝香祛痛搽剂的质量标准提高研究
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| 篇名： | 麝香祛痛搽剂的质量标准提高研究 |
| TITLE： | |
| 摘要： | 目的：优化和提高麝香祛痛搽剂的质量标准。方法：采用薄层色谱（TLC）法对制剂中龙血竭、地黄进行定性鉴别。测定制剂总固体和醚溶性提取物的质量分数。采用气相色谱法测定制剂中麝香酮的含量：色谱柱为Thermo-TG-WAXMS毛细管柱，采用程序升温，检测器为氢火焰离子化检测器，检测器温度为250 ℃，进样口温度为200 ℃，载气为高纯氮气，流速为1.0 ml/min，分流比为5 ∶ 1，进样量为1 μl。结果：龙血竭、地黄的TLC图斑点清晰，分离度好。各批样品总固体≥0.6％，醚溶性提取物≥3.0％。麝香酮检测质量浓度线性范围为15.21～243.36 μg/ml（r＝0.999 8）；精密度、稳定性、重复性试验的RSD＜2％；加样回收率为97.70％～99.63％（RSD＝0.78％，n＝6）。结论：经优化和提高的标准可用于麝香祛痛搽剂的质量控制。 |
| ABSTRACT： | OBJECTIVE：To improve the quality standard of Shexiang qutong liniment. METHODS： TLC was used for qualitative identification of Resina draconis and Rehmannia. The determination of total solids and ether-soluble extracts in the preparation was detected. GC was used for the content determination of muscone： the column was Thermo-TG-WAXMS capillary column by programmed temperature， the detector was FID detector， the detector temperature was 250 ℃， inlet temperature was 200 ℃， carrier gas was high purity nitrogen at a flow rate of 1.0 ml/min， split ratio was 5 ∶ 1， and the injection volume was 1 μl. RESULTS：The TLC pots of R.draconis and Rehmannia were clear with good separation. The total solids in preparations were not less than 0.6％， and extracts were not less than 3.0％. The linear range of muscone concentration was 15.21-243.36 μg/ml（r＝0.999 8）； RSDs of precision， stability and reproducibility tests were lower than 2％； recovery was 97.70％-99.63％（RSD＝0.78％，n＝6）. CONCLUSIONS： The established method can be used for the quality control of Shexiang qutong liniment. |
| 期刊： | 2016年第27卷第12期 |
| 作者： | 张楠，雷成康 |
| AUTHORS： | ZHANG Nan，LEI Chengkang |
| 关键字： | 麝香祛痛搽剂；质量标准；提高；薄层色谱法；气相色谱法 |
| KEYWORDS： | Shexiang qutong liniment； Quality standard； Improvement； TLC； GC |
| 阅读数： | 334 次 |
| 本月下载数： | 2 次 |
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