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盐酸左氧氟沙星与卡络磺钠在0.9％氯化钠注射液中的稳定性考察
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| 篇名： | 盐酸左氧氟沙星与卡络磺钠在0.9％氯化钠注射液中的稳定性考察 |
| TITLE： | |
| 摘要： | 目的：探讨盐酸左氧氟沙星与卡络磺钠在0.9％氯化钠注射液中混合的稳定性，以期为二者的临床配伍使用提供一定的参考。方法：采用高效液相色谱法同时测定。色谱柱为Phenomenex Gemini C18，流动相A为乙腈、流动相B为0.01 mol/L磷酸二氢铵溶液（用磷酸调pH至3.0）（采用梯度洗脱），流速为1.0 ml/min，检测波长为295 nm（盐酸左氧氟沙星）、364 nm（卡络磺钠），柱温为35 ℃，进样量为20 μl。考察二者在0.9％氯化钠注射液中混合后的含量、外观和溶液pH值的变化。结果：盐酸左氧氟沙星、卡络磺钠检测质量浓度线性范围分别为7.03～80.06、1.70～34.04 μg/ml（r＝0.999 5、0.999 8）；精密度、重复性试验的RSD＜2.0％；加样回收率分别为98.75％～100.63％、98.00％～100.83％，RSD分别为0.65％、0.99％（n＝9）；二者在0.9％氯化钠注射液中混合后常温放置6 h内，含量未见明显降低，混合溶液外观和pH值未见明显变化。结论：盐酸左氧氟沙星与卡络磺钠在0.9％氯化钠注射液中混合后，室温放置6 h内较稳定，临床可协同配伍使用。 |
| ABSTRACT： | OBJECTIVE：To explore the stability of levofloxacin hydrochloride and carbazochrome sodium sulfonate in 0.9％ Sodium chloride injection， and provide reference for their compatible use in clinic. METHODS：HPLC was performed on the column of Phenomenex Gemini C18 with mobile phase A of acetonitrile and B of 0.01 mol/L Ammonium biphosphate solution （adjusted to pH 3.0 with phosphoric acid） （gradient elution） at a flow rate of 1.0 ml/min， the detection wavelength was 295 nm for levofloxacin hydrochloride and 364 nm for carbazochrome sodium sulfonate， temperature was 30 ℃， and the injection volume was 20 μl. The changes of contents， appearance and pH value of the solution in the mixture were investigated. RESULTS：The linear range was 7.03-80.06 μg/mL for levofloxacin hydrochloride（r＝0.999 5） and 1.70-34.04 μg/mL for carbazochrome sodium sulfonate（r＝0.999 8）；RSDs of precision and reproducibility tests were no more than 2.0％；recoveries were 98.75％-100.63％ and 98.00％-100.83％， and RSDs were 0.65％ and 0.99％（n＝9）， respectively. In normal temperature， the contents of levofloxacin hydrochloride and carbazochrome sodium sulfonate after mixing with 0.9％ Sodium chloride injection within 6 h showed no significant decrease， and the appearance and pH value showed no obvious changes. CONCLUSIONS：The mixing of levofloxacin hydrochloride and carbazochrome sodium sulfonate with 0.9％ Sodium chloride injection in room temperature is stable within 6 h， they can compatibly use synergistically in clinic. |
| 期刊： | 2016年第27卷第12期 |
| 作者： | 魏秀美 |
| AUTHORS： | WEI Xiumei |
| 关键字： | 高效液相色谱法；盐酸左氧氟沙星；卡络磺钠；0.9％氯化钠注射液；稳定性 |
| KEYWORDS： | HPLC； Levofloxacin hydrochloride； Carbazochrome sodium sulfonate； 0.9％ Sodium chloride injection； Stability |
| 阅读数： | 441 次 |
| 本月下载数： | 2 次 |
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