抗结核药致药物性肝损伤危险因素的Logistic回归分析-中国药房

抗结核药致药物性肝损伤危险因素的Logistic回归分析

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篇名：	抗结核药致药物性肝损伤危险因素的Logistic回归分析
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摘要：	目的：探讨抗结核药致药物性肝损伤的危险因素，为药物性肝损伤的防治提供科学依据。方法：采用回顾性分析的方法，调查410例抗结核药治疗病例，并采用单因素和多因素Logistic回归分析方法分析抗结核药治疗中可能诱发药物性肝损伤的危险因素。结果：单因素回归分析提示性别、肝病史、饮酒史、营养不良与发生药物性肝损伤具有相关性；多因素回归分析显示，女性（OR＝2.320，P＝0.021）、有肝病史（OR＝4.332，P＝0.006）、有饮酒史（OR＝4.512，P＝0.003）、有营养不良（OR＝3.202，P＝0.015）为抗结核药致药物性肝损伤的危险因素，危险程度为有饮酒史＞有肝病史＞有营养不良＞女性。结论：女性、有肝病史、有饮酒史、有营养不良患者使用抗结核药致药物性肝损伤的风险更高，基于相关危险因素的药物性肝损伤预防有助于改善患者的临床症状，减少不良反应发生。
ABSTRACT：	OBJECTIVE：To explore the risk factors of antituberculosis drug-induced liver injury， and provide scientific basis for the prevention and treatment of drug-induced liver injury. METHODS： Retrospective analysis was adopted to investigate 410 patients with antituberculosis treatment， single factor and multi-factor Logistic regression analysis were adopted to analyze the risk factor that may induce liver injury in antituberculosis treatment. RESULTS： Single factor regression analysis showed that gender， hepatitis history and drinking history were associated with drug-induced liver injury， multi-factor regression analysis showed that female（OR＝2.320，P＝0.021），hepatitis history（OR＝4.332，P＝0.006），drinking history（OR＝4.512，P＝0.003） and malnutrition（OR＝3.202，P＝0.015） were risk factors of antituberculosis drug-induced liver injury， and the degree of danger was drinking history＞hepatitis history＞malnutrition＞female. CONCLUSIONS：The antituberculosis drug-induced liver injury is mainly affected by female， hepatitis history， drinking history and malnutrition， the prevention of drug-induced liver injury based on related risk factors is helpful to improve the clinical symptoms and reduce the incidence of adverse reactions.
期刊：	2016年第27卷第12期
作者：	何涛，汪峰，唐武
AUTHORS：	HE Tao，WANG Feng，TANG Wu
关键字：	抗结核药物；药物性肝损伤；危险因素；Logistic回归分析
KEYWORDS：	Antituberculosis drug； Drug-induced liver injury； Risk factor； Logistic regression analysis
阅读数：	157 次
本月下载数：	4 次

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