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布洛芬联合尼美舒利治疗疼痛的临床观察
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| 篇名： | 布洛芬联合尼美舒利治疗疼痛的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察布洛芬联合尼美舒利治疗疼痛的短期疗效和安全性。方法： 84例疼痛患者随机均分为对照组和观察组。对照组患者给予布洛芬缓释胶囊0.3 g，口服，每日2次；观察组患者在对照组治疗的基础上给予尼美舒利胶囊100 mg，口服，每日2次。两组疗程均为7 d。观察两组患者的临床疗效，治疗前后视觉模拟（VAS）评分、生活质量（QOL）评分，凝血指标（凝血酶原时间、凝血酶时间、纤维蛋白原、活化部分凝血活酶时间）及不良反应发生情况。结果：观察组患者总有效率显著高于对照组，差异有统计学意义（P＜0.05）。治疗前，两组患者VAS评分、QOL评分比较，差异均无统计学意义（P＞0.05）。治疗后，两组患者VAS评分均显著低于同组治疗前，且观察组低于对照组，QOL评分均显著高于同组治疗前，且观察组高于对照组，差异均有统计学意义（P＜0.05）。两组患者凝血指标、不良反应发生率比较，差异均无统计学意义（P＞0.05）。结论：布洛芬联合尼美舒利治疗疼痛的短期疗效显著优于单用布洛芬，且安全性相当。 |
| ABSTRACT： | OBJECTIVE：To observe the short-term efficacy and safety of nimesulide combined with ibuprofen in the treatment of pain. METHODS： 84 patients with pain were randomly divided into observation group and control group. Control group was orally given 0.3 g Ibuprofen sustained-release capsule， twice a day. Observation group was additionally given 100 mg Nimesulide capsule， twice a day. The treatment course for both groups was 7 d. Clinical efficacy， visual analogue （VAS） score， quality of life （QOL） score， coagulation indexes （prothrombin time， thrombin time， fibrinogen， activated partial thromboplastin time） before and after treatment， and incidence of adverse reactions in 2 groups were observed. RESULTS： The total effective rate in observation group was significantly higher than control group， the differences were statistically significant（P＜0.05）. Before treatment， there were no significant differences in the VAS score and QOL score between 2 groups（P＞0.05）. After treatment， VAS scores in 2 groups were significantly lower than before， and observation group was lower than control group， QOL scores were significantly higher than before， and observation group was higher than control group， the differences were statistically significant（P＜0.05）. And there were no significant differences in the coagulation indexes and incidence of adverse reactions between 2 groups（P＞0.05）. CONCLUSIONS： The short-term efficacy of ibuprofen combined with nimesulide is superior to ibuprofen alone in the treatment of pain， with similar short-term safety. |
| 期刊： | 2016年第27卷第12期 |
| 作者： | 肖厚平，蔡璐，张爱民 |
| AUTHORS： | XIAO Houping1，CAI Lu2，ZHANG Aimin |
| 关键字： | 布洛芬；尼美舒利；疼痛；短期疗效；安全性 |
| KEYWORDS： | Ibuprofen； Nimesulide； Pain； Short-term efficacy； Safety |
| 阅读数： | 325 次 |
| 本月下载数： | 4 次 |
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