奥美拉唑联合活血化瘀通络方对糖尿病胃轻瘫胃动力障碍疗效及相关指标的影响-中国药房

奥美拉唑联合活血化瘀通络方对糖尿病胃轻瘫胃动力障碍疗效及相关指标的影响

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篇名：	奥美拉唑联合活血化瘀通络方对糖尿病胃轻瘫胃动力障碍疗效及相关指标的影响
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摘要：	目的：探讨奥美拉唑联合活血化瘀通络方对糖尿病胃轻瘫胃动力障碍疗效及相关指标的影响。方法：92例糖尿病胃轻瘫胃动力障碍患者随机均分为观察组和对照组。两组患者均给予糖尿病膳食指导与运动指导，对于合并代谢紊乱和高血压者给予调脂和降压等常规治疗。在此基础上，对照组患者口服奥美拉唑肠溶胶囊20 mg，每日1次；观察组患者在对照组治疗的基础上给予活血化瘀通络方水煎服，取汁300 ml，每次150 ml，每日2次。两组疗程均为14 d。观察两组患者的临床疗效，治疗前后空腹血糖、糖化血红蛋白、全血黏度、胃动素、胃泌素、胃半排空时间（GET1/2）及不良反应发生情况。结果：观察组患者总有效率显著高于对照组，差异有统计学意义（P＜0.05）。治疗前，两组患者空腹血糖、糖化血红蛋白、全血黏度、胃动素、胃泌素、GET1/2比较，差异均无统计学意义（P＞0.05）。治疗后，两组患者空腹血糖、糖化血红蛋白、全血黏度、胃动素、胃泌素、GET1/2均显著低于同组治疗前，且观察组低于对照组，差异均有统计学意义（P＜0.05）。两组患者治疗期间均未见明显不良反应发生。结论：在常规治疗的基础上，奥美拉唑联合活血化瘀通络方治疗糖尿病胃轻瘫胃动力障碍的疗效显著优于单用奥美拉唑，可降低血糖，改善血流动力学，且安全性相当。
ABSTRACT：	OBJECTIVE：To explore the effects of omeprazole combined with Huxue huayu tongluo formula on the efficacy and relevant indexes of diabetic gastroparesis gastric motility disorder. METHODS：92 patients with diabetic gastroparesis gastric motility disorder were randomly divided into observation group and control group. All patients were given diabetes dietary guidance and exercise guidance， and patients with combined metabolic disorders and hypertension were given lipid lowering， antihypertensive and other conventional treatment； based on it， control group was orally given 20 mg Omeprazole enteric-coated capsule， once a day； observation group was additionally given 300 ml Huxue huayu tongluo formula， 150 ml once， twice a day. The treatment course for both groups was 14 d. Clinical efficacy， fasting blood glucose， glycated hemoglobin， whole blood viscosity level， motilin， gastrin， half gastric emptying time （GET1/2） before and after treatment， and the incidence of adverse reactions in 2 groups were observed. RESULTS：The total effective rate in observation group was significantly higher than control group， the difference was statistically significant（P＜0.05）； before treatment， there were no significant differences in the fasting blood glucose， glycated hemoglobin， whole blood viscosity level， motilin， gastrin and GET1/2（P＞0.05）； after treatment， fasting blood glucose， glycated hemoglobin， whole blood viscosity level， motilin， gastrin and GET1/2 in 2 groups were significantly lower than before， and observation group was lower than control group， the differences were statistically significant（P＜0.05）； and there were no adverse reactions during treatment. CONCLUSIONS： Based on the conventional treatment， the efficacy of omeprazole combined with Huxue huayu tongluo formula is superior to omeprazole alone for diabetic gastroparesis gastric motility disorder， it can significantly reduce blood glucose and improve hemodynamics， with similar safety.
期刊：	2016年第27卷第12期
作者：	贺东黎，刁云辉
AUTHORS：	HE Dongli，DIAO Yunhui
关键字：	活血化瘀通络方；奥美拉唑；糖尿病胃轻瘫；胃动力障碍；疗效；相关指标
KEYWORDS：	Huxue huayu tongluo formula； Omeprazole； Diabetic gastroparesis； Gastric motility disorders； Efficacy； Relevant indexes
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