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醒脑静与盐酸纳洛酮治疗昏迷脑出血的临床观察
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| 篇名： | 醒脑静与盐酸纳洛酮治疗昏迷脑出血的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察醒脑静与盐酸纳洛酮治疗昏迷脑出血的疗效及安全性。方法：将126例昏迷脑出血患者按随机数字表法分为醒脑静组和盐酸纳洛酮组，各63例。两组患者均根据身体情况采用20％甘露醇和/或地塞米松静脉滴注进行脱水治疗，并进行其他基础治疗。醒脑静组患者给予醒脑静注射液20 ml加入5％葡萄糖注射液250 ml，ivgtt，qd；盐酸纳洛酮组患者给予盐酸纳洛酮注射液4 mg加入5％葡萄糖注射液250 ml，ivgtt，qd。观察两组患者的临床疗效、住院时间、出院前后神经功能缺损（NIHSS）评分、治疗前后格拉斯哥昏迷（GCS）评分和脑血肿量，并记录不良反应情况。结果：盐酸纳洛酮组患者临床总有效率为88.89％，显著高于醒脑静组的74.61％，差异有统计学意义（P＜0.05）；盐酸纳洛酮组患者的平均住院时间为（17.5±8.8）d，显著低于醒脑静组的（28.4±10.3）d，差异有统计学意义（P＜0.05）。两组患者出院前、出院后3个月的NIHSS评分显著低于入院前，且出院后3个月盐酸纳洛酮组患者的NIHSS评分显著低于醒脑静组，差异均有统计学意义（P＜0.05）。与治疗前比较，治疗后两组患者的GCS评分显著升高，脑血肿量显著降低，且盐酸纳洛酮组明显优于醒脑静组，差异有统计学意义（P＜0.05）。两组患者均未见明显不良反应。结论：盐酸纳洛酮较醒脑静能明显促进昏迷脑出血患者神经功能恢复，提高临床疗效，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To observe therapeutic efficacy and safety of Xingnaojing and naloxone hydrochloride in the treatment of coma patients with cerebral hemorrhage. METHODS： 126 coma patients with cerebral hemorrhage were randomly assigned into Xingnaojing group and naloxone hydrochloride group with 63 cases in each group. Both groups were given 20％ mannitol or and dexamethasone intravenously for dehydration therapy and other basic treatment. Xingnaojing group was given Xingnaojing injection 20 ml added into 5％ Glucose injection 250 ml， ivgtt， qd； naloxone hydrochloride group was given Naloxone hydrochloride injection 4 mg added into 5％ Glucose injection 250 ml， ivgtt， qd. Clinical efficacy， length of stay， NIHSS before and after discharge， GCS and cerebral hematoma volume before and after treatment were observed in 2 groups， and ADR was recorded. RESULTS： The total effective rate of observation group was 88.89％， which was significantly higher than that of control group （74.61％）， with statistical significance （P＜0.05）； average length of stay in observation group was （17.5±8.8）d， which was significantly lower than （28.4±10.3）d of control group， with statistical significance （P＜0.05）. NIHSS of patients before discharge and 3 months after discharge were significantly lower than before admission， and the naloxone hydrochloride group was lower than the Xinnaojing group， with statistical significance （P＜0.05）. After treatment， GCS were increased significantly and cerebral hematoma volume of 2 groups were significantly lower before treatment， and the naloxone hydrochloride group was lower than the Xingnaojing group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： Naloxone hydrochloride is better than Xingnaojing in improving neurological recovery and clinical efficacy， and shows good safety. |
| 期刊： | 2016年第27卷第11期 |
| 作者： | 王晟，毛新龙，邹军辉 |
| AUTHORS： | WANG Sheng，MAO Xinlong，ZOU Junhui |
| 关键字： | 醒脑静；盐酸纳洛酮；昏迷脑出血；临床疗效 |
| KEYWORDS： | Xingnaojing； Naloxone hydrochloride； Coma cerebral hemorrhage； Clinical efficacy |
| 阅读数： | 340 次 |
| 本月下载数： | 1 次 |
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