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重庆地区2014年幽门螺杆菌临床分离株耐药性分析
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| 篇名： | 重庆地区2014年幽门螺杆菌临床分离株耐药性分析 |
| TITLE： | |
| 摘要： | 目的：了解重庆地区幽门螺杆菌（Hp）临床分离株对常用抗菌药物的体外敏感性及耐药性，并分析耐药原因。方法：Hp菌株取自重庆地区4家医院2014年4－12月胃镜室，随机取患者胃黏膜活检标本189例，分离培养后进行体外抗菌药物敏感性试验，检测Hp对甲硝唑、克拉霉素、阿莫西林、左氧氟沙星、四环素、呋喃唑酮的敏感性，并与2005年数据进行对比。同时问卷调查医师在Hp治疗中抗菌药物的选择倾向性。结果：共培养出Hp 63株，其对甲硝唑、克拉霉素、阿莫西林、左氧氟沙星、四环素及呋喃唑酮的耐药率分别为100％、28.6％、0、34.9％、0、0。28.6％的菌株同时对甲硝唑及克拉霉素耐药。Hp对甲硝唑的耐药率较2005年有所升高，对呋喃唑酮的耐药率有所降低，差异均有统计学意义（P＜0.05）。医师在Hp治疗中抗菌药物选择倾向最高的为阿莫西林+克拉霉素（42.8％）。结论：重庆地区Hp对甲硝唑、克拉霉素及左氧氟沙星的耐药率较高，这可能与医师选择倾向及同种属抗菌药物大量使用相关。建议重庆地区Hp治疗可选用阿莫西林、呋喃唑酮及四环素。 |
| ABSTRACT： | OBJECTIVE： To investigate the sensitivity and drug resistance of Helicobacter pylori （Hp） clinical isolated to commonly used antibiotics in Chongqing area， and to analyze the reasons for drug resistance. METHODS： Hp strains were collected from gastroscope room of 4 hospitals from Chongqing area during Apr. to Dec. 2014， and gastric biopsy samples were randomly collected from 189 patients. Isolated Hp strains were cultured and used for antimicrobial susceptibility test in vitro. The sensitivity of Hp to metronidazole， clarithromycin， amoxicillin， levofloxacin， tetracycline and furazolidone were determined and compared with results in year of 2005. At the same time， questionnaire survey was conducted among physicians about their antibacterial choice in Hp treatment. RESULTS： A total of 63 Hp strains were cultured. Of these strains， 100％ were resistant to metronidazole， 28.6％ were resistant to clarithromycin， and 34.9％ were resistant to tetracycline. Resistance to amoxicillin， furazolidone or levofloxacin were not found in the study. Notably， 28.6％ of the isolates were found to be resistant to both metronidazole and clarithromycin； resistance to metronidazole had increased in 2005， while its resistance to furazolidone decreased， with statistical significance （P＜0.05）. In questionnaire survey， physicans favored to use amoxicillin+clarithromycin in Hp treatment. CONCLUSIONS： In general， resistance to metronidazole， levofloxacin and clarithromycin are higher， which could be due to physicians’ choice and to the frequent use of this antibiotics. These results suggest that amoxicillin， furazolidone or tetracycline is better choice in the treatment of Hp infections in Chongqing area. |
| 期刊： | 2016年第27卷第11期 |
| 作者： | 冷佳源，袁桂林，唐茜，沈薇 |
| AUTHORS： | LENG Jiayuan，YUAN Guilin，TANG Qian，SHEN Wei |
| 关键字： | 耐药性；幽门螺杆菌；重庆地区；甲硝唑；阿莫西林 |
| KEYWORDS： | Drug resistance； Helicobacter pylori； Chongqing area； Metronidazole； Amoxicillin |
| 阅读数： | 256 次 |
| 本月下载数： | 2 次 |
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