急性复发性脑梗死患者发生阿司匹林抵抗的相关性分析
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篇名: 急性复发性脑梗死患者发生阿司匹林抵抗的相关性分析
TITLE:
摘要: 目的:探讨急性复发性脑梗死患者发生阿司匹林抵抗(AR)的相关性。方法:208例急性脑梗死患者分为初发组(108例)和复发组(100例),再根据血小板聚集率分为阿司匹林抵抗(AR)+阿司匹林半抵抗(ASR)组、阿司匹林敏感(AS)组两个亚组。比较初发组和复发组患者AR+ASR的发生率,复发组患者中AR+ASR和AS两个亚组患者的临床相关指标[年龄、性别、高血压、高血脂、糖尿病、冠心病、吸烟史、过量饮酒史、体质量指数(BMI)、超敏C反应蛋白(hs-CRP)、血小板计数(PLT)、空腹血糖(FPG)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)],并对差异有统计学意义的指标进行Logistic回归分析。结果:复发组患者AR+ASR发生率显著高于初发组,差异有统计学意义(P<0.05)。复发组中AR+ASR亚组患者高血脂、糖尿病、过量饮酒史、hsCRP、LDL均显著高于AS组,差异均有统计学意义(P<0.05)。Logistic回归分析显示,高血脂[OR=4.710,95%Cl(1.985,14.359),P=0.005]、糖尿病[OR=4.916,95%Cl(0.962,18.478),P=0.038]、hs-CRP[OR=1.002,95%Cl(0.653,2.253),P=0.003]均为急性复发性脑梗死患者发生AR的危险因素。结论:急性复发性脑梗死患者易发生AR,糖尿病、高血脂和hs-CRP可能是急性复发性脑梗死患者发生AR的危险因素。
ABSTRACT: OBJECTIVE:To analysis the correlation of aspirin resistance (AR) in patients with acute recurrent cerebral infarction. METHODS: 208 patients with acute cerebral infarction were divided into primary group (108 cases) and recurrent group (100 cases). And they were further divided into AR group+aspirin semi resistance (ASR) group and aspirin sensitivity (AS) group based on platelet aggregation rate. The incidences of AR+ASR in primary group and recurrent group were compared; clinical relevant indicators [age, gender, hypertension, high cholesterol, diabetes, coronary heart disease, smoking history, history of excessive alcohol consumption, body mass index (BMI), high-sensitivity C-reactive protein (hs-CRP), platelet count (PLT), fasting plasma glucose (FPG), triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL) and low density lipoprotein (LDL)] were also compared, and Logistic regression analysis was conducted for the indicators with significant differences. RESULTS: The incidences of AR+ASR in recurrent group were significantly higher than primary group, the differences were statistically significant (P<0.05). High cholesterol, diabetes, history of excessive alcohol consumption, hs-CRP and LDL in the AR+ASR subgroups of recurrent group were significantly higher than AS group, the differences were statistically significant(P<0.05). Logistic regression analysis showed, high cholesterol[OR=4.710,95% Cl(1.985,14.359),P=0.005], diabetes [OR=4.916,95% Cl(0.962,18.478), P=0.038] and hsCRP [OR=1.002, 95% Cl(0.653,2.253),P=0.003] were the risk factors for AR occurrence in recurrent acute cerebral infarction. CONCLUSIONS: The incidence of AR in patients with acute recurrent cerebral infarction is significantly higher than primary patients, and diabetes, high cholesterol and hsCRP may be the risk factors for AR occurrence in recurrent acute cerebral infarction.
期刊: 2016年第27卷第9期
作者: 朱筱琦,陆学胜
AUTHORS: ZHU Xiaoqi,LU Xuesheng
关键字: 急性脑梗死;复发;阿司匹林抵抗;相关性
KEYWORDS: Acute cerebral infarction; Recurrence; Aspirin resistance; Correlation
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