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氢氯噻嗪联合酚妥拉明对高血压急症患者相关指标的影响
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| 篇名： | 氢氯噻嗪联合酚妥拉明对高血压急症患者相关指标的影响 |
| TITLE： | |
| 摘要： | 目的：探讨氢氯噻嗪联合酚妥拉明对高血压急症患者相关指标的影响。方法： 150例高血压急症患者随机均分为酚妥拉明组、氢氯噻嗪组和联用组。各组患者均给予卡托普利等常规治疗。在此基础上，酚妥拉明组患者给予甲磺酸酚妥拉明注射液20 mg，加入5％葡萄糖注射液250 ml中，静脉滴注，30～40滴/min；氢氯噻嗪组患者给予氢氯噻嗪片50 mg，口服；联用组患者给予甲磺酸酚妥拉明注射液（用法用量同酚妥拉明组）+氢氯噻嗪片（用法用量同氢氯噻嗪组）。各组患者均在治疗后10、30、60 min时观察收缩压（SBP）、舒张压（DBP）、平均动脉压（MAP）、心率（HR）、心脏指数（CI）以及外周阻力指数（TPRI），并记录不良反应发生情况。结果：治疗后，联用组和酚妥拉明组患者SBP、DBP、MAP、TPRI水平均显著低于同组治疗前，随治疗时间的延长逐渐降低，而联用组低于酚妥拉明组和氢氯噻嗪组；CI水平显著高于同组治疗前，随治疗时间的延长逐渐升高，且联用组高于酚妥拉明组和氢氯噻嗪组；氢氯噻嗪组患者仅治疗后60 min SBP、DBP、MAP、TPRI水平低于同组治疗前及治疗后10、30 min，CI水平高于同组治疗前及治疗后10、30 min，差异均有统计学意义（P＜0.05）。各组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：在常规治疗的基础上，氢氯噻嗪联合酚妥拉明能显著改善高血压急症患者的血压、心功能，且安全性较好。 |
| ABSTRACT： | OBJECTIVE：To explore the effects of hydrochlorothiazide combined with phentolamine on related indicators of hypertensive emergency. METHODS： 150 patients with hypertensive emergency were randomly divided into phentolamine group， hydrochlorothiazide group and combination group. All patients were given Captopril tablet and other Conventional treatment. Based on it， phentolamine group was given 20 mg Phentolamine mesylate injection， adding into 250 ml 5％ Glucose injection by intravenous infusion， with drip rate of 30-40 mg/min； hydrochlorothiazide group was given 50 mg Hydrochlorothiazide tablet， orally. Combination group was given Hydrochlorothiazide tablet （the same dosage with hydrochlorothiazide group） + Phentolamine mesylate injection （the same dosage with phentolamine group）. Systolic blood pressure （SBP）， diastolic blood pressure （DBP）， arterial pressure （MAP）， heart rate （HR）， cardiac index （CI） and the peripheral resistance （TPRI） in all groups were observed after 10， 30 and 60 min. RESULTS： After treatment， the SBP， DBP， MAP and TPR levels in combination group and phentolamine group were significantly lower than before and gradually decreased by time extension，and combination group was lower than phentolamine group and hydrochlothiazide group，CI level was significantly higher than before and gradually increased by time extension，and combination group was higher than phentolainine group and hydrochlothiazide group； after 60 min， SBP， DBP， MAP and TPRI levels in hydrochlorothiazide group were lower than before and after 10 and 30 min， CI level was higher than before and after 10 and 30 min， the differences were statistically significant（P＜0.05）. And there was no significant difference in the incidence of adverse reactions （P＞0.05）. CONCLUSIONS：Based on the conventional treatment， hydrochlorothiazide combined with phentolamine can significantly improve the blood pressure and cardiac functions， with good safety. |
| 期刊： | 2016年第27卷第9期 |
| 作者： | |
| AUTHORS： | 郭林，史良俊，范学科 |
| 关键字： | 氢氯噻嗪；酚妥拉明；高血压急症 |
| KEYWORDS： | Hydrochlorothiazide； Phentolamine； Hypertensive emergency |
| 阅读数： | 496 次 |
| 本月下载数： | 2 次 |
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