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乌司他丁治疗急性胰腺炎患者的临床观察
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| 篇名： | 乌司他丁治疗急性胰腺炎患者的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察乌司他丁治疗急性胰腺炎患者的临床疗效。方法：选取急性胰腺炎患者80例，按随机数字表法分为对照组和观察组，各40例。对照组患者给予肠胃减压、止痛解痉、抗感染、补充液体、调节电解质紊乱、改善体内微循环等常规治疗；观察组患者在对照组基础上加用乌司他丁10万单位加入5％葡萄糖注射液250 ml中，ivgtt，bid，症状改善后按qd给药，症状完全消失即停止用药。两组患者均治疗8 d。观察两组患者治疗前后血清白细胞介素6（IL-6）、肿瘤坏死因子α（TNF-α）水平及临床症状、体征和实验室检查指标改善时间，并评价临床疗效。结果：治疗后，观察组患者血清IL-6、TNF-α水平均明显低于对照组，临床症状、体征和实验室检查指标改善时间显著短于对照组，差异均有统计学意义（P＜0.01）。观察组患者有效率（95.00％）显著高于对照组（70.00％），差异有统计学意义（P＜0.05）。结论：乌司他丁能明显减少急性胰腺炎患者炎性反应，改善患者临床症状，促进病情恢复，提高临床疗效。 |
| ABSTRACT： | OBJECTIVE： To observe therapeutic efficacy of ulinastatin in the treatment of acute pancreatitis. METHODS： A total of 80 acute pancreatitis patients were randomly divided into control group and observation group， with 40 cases in each group. Control group was given conventional treatment as gastrointestinal decompression， analgesia and spasmolysis， anti-infective treatment， fluid replacement， electrolyte disturbances balance， in vivo microcirculation improvement； observation group was additional given ulinastatin 100 000 U added into 5％ Glucose injection 250 ml， ivgtt， bid， on the basis of control group， and then given medicine qd after improving symptoms； finally， stopped taking medicine immediately the symptom disappeared. Both groups was given 8d of treatment. Serum levels of IL-6 and TNF-α were observed in 2 groups before and after treatment， and clinical symptom， the time of sign and lab index improvement were also observed. Clinical efficacy was evaluated. RESULTS： After treatment， serum levels of IL-6 and TNF-α in observation group was significantly lower than in control group； the time of clinical symptom and sign， lab indicator improvement were significantly shorter than in control group， with statistical significance （P＜0.01）. The effective rate （95.00％） of observation group was significantly higher than that （70.00％） of control group， with statistical significance （P＜0.05）. CONCLUSIONS： Ulinastatin can significantly reduce acute pancreatitis significantly， improve clinical symptom， promote disease recovery and clinical efficacy. |
| 期刊： | 2016年第27卷第8期 |
| 作者： | 尹宏伟，周慧芬 |
| AUTHORS： | YIN Hongwei，ZHOU Huifen |
| 关键字： | 乌司他丁；白细胞介素；肿瘤坏死因子；急性胰腺炎；疗效 |
| KEYWORDS： | Ulinastatin； IL； TNF-α； Acute pancreatitis； Therapeutic efficacy |
| 阅读数： | 371 次 |
| 本月下载数： | 3 次 |
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