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醋酸泼尼松联合来氟米特治疗IgA肾病的临床观察
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| 篇名： | 醋酸泼尼松联合来氟米特治疗IgA肾病的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察醋酸泼尼松联合来氟米特治疗免疫球蛋白A（IgA）肾病的疗效及安全性。方法：选取IgA肾病患者80例，按随机数字表法分为观察组和对照组，各40例。对照组患者给予醋酸泼尼松1.0 mg/kg，qd，6周后逐渐减量，至12周时降至0.5 mg/kg；观察组患者在对照组基础上加用来氟米特50 mg，qd，3 d后降至20 mg。两组患者均治疗3个月。观察两组患者治疗后临床疗效及24 h尿蛋白定量、血肌酐（SCr）、血尿素氮（BUN）水平，并记录治疗过程中的不良反应情况。结果：观察组患者总有效率（95.0％）显著高于对照组（75.0％），差异有统计学意义（P＜0.05）；治疗后，两组患者的24 h尿蛋白定量、SCr、BUN水平均显著降低，且观察组低于对照组，差异有统计学意义（P＜0.05）。观察组患者的不良反应发生率（0）显著低于对照组（7.5％），差异有统计学意义（P＜0.05）。结论：醋酸泼尼松联合来氟米特治疗IgA肾病患者效果显著，且不会增加患者的不良反应。 |
| ABSTRACT： | OBJECTIVE： To observe therapeutic efficacy and safety of prednisone acetate combined with leflunomide in the treatment of IgA nephropathy. METHODS： 80 patients with IgA nephropathy were randomly divided into observation group and control group， with 40 cases in each group. Control group was given prednisone acetate 1.0 mg/kg， qd， 6 weeks later， decreasing gradually， decreasing to 0.5 mg/kg in 12th week； observation group was additionally given leflunomide 50 mg， qd， 3 days later decreasing to 20 mg. Both groups were given 3 months of treatment. Clinical efficacy， 24 h urinary protein quantification， Scr and BUN levels were observed in 2 groups after treatment， and ADR were recorded during treatment. RESULTS： Total effective rate of observation group （95.0％） was significantly higher than that of control group （75.0％）， with statistical significance （P＜0.05）. After treatment， 24 h urinary protein quantification， Scr and BUN levels of observation group were significantly lower than those of control group， with statistical significance （P＜0.05）. The incidence of ADR in observation group （0） was significantly lower than in control group （7.5％）， with statistical significance （P＜0.05）. CONCLUSIONS： Prednisone acetate combined with leflunomide has significant effect on IgA nephropathy， and will not increase the occurrence of ADR. |
| 期刊： | 2016年第27卷第8期 |
| 作者： | 李登峰，任金香 |
| AUTHORS： | LI Dengfeng，REN Jinxiang |
| 关键字： | 醋酸泼尼松；来氟米特；免疫球蛋白A肾病；安全性 |
| KEYWORDS： | Prednisone acetate； Leflunomide； IgA nephropathy； Effectiveness |
| 阅读数： | 348 次 |
| 本月下载数： | 3 次 |
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