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羧甲淀粉钠治疗反复呼吸道感染患儿的疗效观察
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| 篇名： | 羧甲淀粉钠治疗反复呼吸道感染患儿的疗效观察 |
| TITLE： | |
| 摘要： | 目的：观察羧甲淀粉钠治疗反复呼吸道感染（RRI）患儿的临床疗效。方法：选取RRI患儿110例，按随机数字表法分为观察组和对照组，各55例。对照组患儿给予抗感染、抗病毒、退热及止咳化痰等常规治疗，观察组患儿在对照组基础上口服羧甲淀粉钠溶液治疗，其中患儿＜4岁7 ml，4～7岁10 ml，＞7岁15 ml，tid。两组患儿均连续治疗3个月。观察两组患儿治疗前后细胞免疫功能指标CD4+、CD8+、CD4+/CD8+水平及体液免疫功能指标免疫球蛋白（Ig）G、IgA、IgM水平变化，并评估两组患儿的临床疗效。结果：对照组患儿治疗前后CD4+、CD8+、CD4+/CD8+水平比较，差异无统计学意义（P＞0.05）；治疗后，观察组患儿CD4+及CD4+/CD8+水平明显升高，且明显高于对照组，CD8+水平明显降低，且明显低于对照组，差异均有统计学意义（P＜0.05）。对照组患儿治疗前后IgG、IgA、IgM水平比较，差异无统计学意义（P＞0.05）；治疗后，观察组患儿IgG、IgA、IgM水平均明显升高，且明显高于对照组，差异有统计学意义（P＜0.05）。观察组患儿总有效率为92.73％，明显高于对照组（78.18％），差异有统计学意义（P＜0.05）。结论：羧甲淀粉钠治疗RRI患儿的疗效较确切，且能明显改善患儿的细胞免疫及体液免疫功能。 |
| ABSTRACT： | OBJECTIVE： To observe clinical efficacy of carboxymethyl starch in the treatment of recurrent respiratory infection （RRI） children. METHODS： 110 RRI children were selected and randomly divided into observation group and control group， with 55 children in each group. Control group was given routine treatment， such as anti-infection， anti-virus， abatement of fever， relieving cough， phlegm transformation and etc. Observation group was additionally given Carboxymethyl starch sodium solution （7 ml for ＜4 year-old， 10 ml for 4-7 year-old， 15 ml for ＞7 year-old） on the basis of control group. Both groups received consecutive treatment for 3 months. The changes of cellular immunity function index CD4+， CD8+ and CD4+/CD8+ and humoral immunity index IgG， IgA and IgM were observed in 2 groups before and after treatment， and clinical efficacy was evaluated in 2 groups. RESULTS： There was no statistical significance in CD4+， CD8+ and CD4+/CD8+ levels of control group before and after treatment （P＞0.05）； after treatment， CD4+ and CD4+/CD8+ of observation group obviously increased， while CD8+ level obviously declined； the observation group was better than control group， with statistical significance （P＜0.05）. There was no statistical significance in IgG， IgA and IgM levels of control group， with statistical significance （P＞0.05）； after treatment， IgG， IgA and IgM levels of control group increased significantly， and the observation group was better than control group， with statistical significance （P＜0.05）. Total effective rate of observation group was 92.73％， which was much higher than that in control group （78.18％）， with statistical significance （P＜0.05）. CONCLUSIONS： Carboxymethyl starch has definite therapeutic efficacy on RRI， and can obviously improve cellular and humoral immunity function. |
| 期刊： | 2016年第27卷第8期 |
| 作者： | 王伟文，阎云芸 |
| AUTHORS： | WANG Weiwen，YAN Yunyun |
| 关键字： | 反复呼吸道感染；羧甲淀粉钠；细胞免疫；体液免疫 |
| KEYWORDS： | Recurrent respiratory infection； Carboxymethyl starch； Cellular immunity； Humoral immunity |
| 阅读数： | 287 次 |
| 本月下载数： | 2 次 |
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