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某院1 731例药品不良反应报告分析
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| 篇名： | 某院1 731例药品不良反应报告分析 |
| TITLE： | |
| 摘要： | 目的：了解医院药品不良反应（ADR）发生的特点及规律，为临床合理用药提供参考。方法：收集某院2002 年1 月－2015 年7 月通过网络系统向国家ADR监测中心上报的1 731 份ADR 报告，分别按患者性别、年龄、因果关系评价、上报人员身份、ADR转归、涉及药品、给药途径、药物剂型、ADR累及器官/系统及主要临床表现等进行描述性统计分析。结果：1 731份ADR报告中，男性患者640例，女性患者1 091 例；41～60岁、≥61岁患者各有676例、568例；严重的ADR 86例，一般的ADR 1 645例，新的ADR 249例，其中严重的ADR 19例； ADR因果关系评价多为“可能”（572例）和“很可能”（859例）；上报人员大部分为医师（1 290例，74.52％），其次为药师（323例，18.66％）和护士（118例，6.82％）；大部分患者ADR结果为好转和痊愈；ADR报告中涉及给药途径16种，其中口服、静脉滴注为主要给药途径，合计占92.95％；ADR报告中涉及32 种药物剂型，以注射剂、片剂和胶囊为主，占总剂型的86.76％。结论：临床应加强 ADR的监测和报告工作，尽可能减少静脉用药，特别应注意老年患者用药安全性，促进临床合理用药，保障患者用药安全。 |
| ABSTRACT： | OBJECTIVE： To investigate the regularity and characteristics of adverse drug reaction （ADR） in our hospital， to reduce the incidence of ADR， and to provide reference for clinical rational drug use. METHODS： 1 731 ADR cases reported by our hospital during Jan. 2002 to Jul. 2015 to national ADR monitoring center through the network system were selected and analyzed statistically in respects of gender， age， related drugs， route of administration， causal relationship evaluation， reporting personnel status， ADR results and drug dosage form organs or systems involved in ADR and manifestation. RESULTS： There were a total of 1 731 ADR patients， among which 640 cases were male， and 1 091 cases were female； patients aged 41-60， ≥61 were 676， 568 cases； there were 86 cases of severe ADR and 1 645 cases of general ADR， 249 cases of new ADR， include 19 cases of severe ADR； causal relationship evaluation of ADR was “impossible” （572 cases） and “very likely” （859 cases） as the vast majority of staff reporting； the most of reporters were doctors （1 290 cases， 74.52％）， followed by pharmacists （323 cases， 18.66％） and nurses （118 cases， 6.82％）； ADR of most patients were improved and recovered. There were 16 routes of administration in ADR cases， among which intravenous infusion and oral administration were the main route of administration， accounting for 92.95％； ADR reports involved 32 kinds of dosage form， which mainly were injection， tablets and capsules， accounting for 86.76％. CONCLUSIONS： Great importance should be attached to ADR monitoring and reporting. We also should reduce the use of intravenous drugs， pay attention to the safety of drug use in elderly patients， promote clinical rational drug use， and ensure the safety of patients. |
| 期刊： | 2016年第27卷第8期 |
| 作者： | 钱妍，何晶晶，明鑫，蒲洋洋，胡敏，杜成凤，邓丹 |
| AUTHORS： | QIAN Yan，HE Jingjing，MING Xin，PU Yangyang，HU Min，DU Chengfeng，DENG Dan |
| 关键字： | 药品不良反应；报告；合理用药；分析 |
| KEYWORDS： | ADR； Report； Rational drug use； Analysis |
| 阅读数： | 306 次 |
| 本月下载数： | 5 次 |
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