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我院社区获得性肺炎患者抗感染治疗的回顾性分析
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| 篇名： | 我院社区获得性肺炎患者抗感染治疗的回顾性分析 |
| TITLE： | |
| 摘要： | 目的：为社区获得性肺炎（CAP）患者合理使用抗菌药物提供参考。方法：采用药品用药频度（DDDs）方法，应用SPSS 19.0统计软件对我院2014年1－12月收治的342例住院CAP患者的病历资料进行回顾性分析。根据年龄将患者分为青少年组、青年组、中年组及老年组，统计、分析其临床基本资料与抗菌药物使用情况。结果：选入的342例住院CAP患者中，320例患者进行了微生物学检查，总微生物送检率为93.57％；痰培养和血培养病例共67例检出病原菌，阴性率20.18％；338例患者（98.83％）使用了抗菌药物，其余4例拒绝抗感染治疗。我院选用的经验性抗菌药物主要为β-内酰胺类（50.07％）、喹诺酮类（35.70％）和大环内酯类（9.80％）。住院CAP患者以二联用药为主，在二联用药中以头孢菌素类联合喹诺酮类最为多见，共计178例次（占53.61％）。治疗期间，共有17例患者发生药品不良反应，总发生率为5.03％。结论：我院住院CAP患者微生物学检查的送检率较高，但培养结果仍需要根据患者的临床体征辩证分析。经验性抗感染治疗以β-内酰胺类、喹诺酮类和大环内酯类抗菌药物单用或联用为主，基本符合我国《社区获得性肺炎诊断和治疗指南》。 |
| ABSTRACT： | OBJECTIVE： To provide reference for rational use of antibiotics in community-acquired pneumonia （CAP） patients. METHODS： Medical records of 342 CAP inpatients in our hospital during Jan.-Dec. in 2014 were analyzed retrospectively by DDDs and SPSS 19.0 statistical software. According to the age， the patients were divided into youth group， the young group， middle age group and elderly group， and clinical information and the use of antibiotics were analyzed statistically. RESULTS： Microbiological examination of 320 of 342 CAP inpatients were performed with detection rate of 93.57％； sputum culture， blood culture and PCT were conducted in 67 case to find out pathogenic bacteria with negative rate of 20.18％. 338 patients had used antibiotics （98.83％）， and other 4 patients refused anti-infective treatment. Selected empirical antibiotics of our hospital were mainly β-lactam （50.07％）， quinolones （35.70％） and macrolides （9.80％）. CAP inpatients were mainly given two-drug therapy， of which cephalosporin combined with quinolone were most common， including 178 cases in total （53.61％）. During treatment， 17 patients suffered from ADR， with incidence of 5.03％. CONCLUSIONS： The detection rate from patients with CAP in our hospital is high in microbiological examination， but culture results should be analyzed dialectically according to clinical signs. Empirical anti-infective therapy mainly include β-lactams， quinolones and macrolides antibiotics alone or in combination with， basically meet the guideline for CAP Diagnosis and Therapy Guideline. |
| 期刊： | 2016年第27卷第8期 |
| 作者： | 苏丹，徐姗，王林晓 |
| AUTHORS： | SU Dan，XU Shan，WANG Linxiao |
| 关键字： | 社区获得性肺炎；抗菌药物；抗感染治疗；指南；回顾性分析 |
| KEYWORDS： | Community-acquired pneumonia； Antibiotics； Anti-infective treatment； Guideline； Retrospective analysis |
| 阅读数： | 353 次 |
| 本月下载数： | 3 次 |
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