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基于冷热板示差法探究黄连-肉桂药对配伍前后的药性变化
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| 篇名： | 基于冷热板示差法探究黄连-肉桂药对配伍前后的药性变化 |
| TITLE： | |
| 摘要： | 目的：探究黄连-肉桂药对配伍前后药性的变化。方法：将小鼠随机分为正常组、体虚（限食游泳法复制模型）组、体虚+黄连组、体虚+肉桂组、体虚+药对组、体盛（高蛋白饮食法复制模型）组、体盛+黄连组、体盛+肉桂组和体盛+药对组，每组10只。造模成功后，每组小鼠均按20 g（生药）/（kg·d） ig相应药物，正常组ig等体积生理盐水，连续7 d。记录小鼠在高温区的停留比例，检测脏器指数和生化指标钠/钾ATP酶（Na+/K+-ATPase）、钙/镁ATP酶（Ca2+/Mg2+-ATPase）、总抗氧化能力、超氧化物歧化酶活性以及血清中去甲肾上腺素、多巴胺含量等。结果：与正常组比较，体虚组小鼠在高温区停留比例升高，肝脏指数、脾脏指数、肾脏指数及生化指标活性或者含量降低（P＜0.05）；体盛组小鼠各项指标的变化趋势与体虚组相反，除高温区的停留比例外上述指标差异有统计学意义（P＜0.05）。与体虚/体盛组比较，体虚/体盛+黄连组小鼠在高温区的停留比例、肝脏指数升高，生化指标的活性或者含量降低（P＜0.05）；体虚/体盛+肉桂组各指标变化趋势与体虚/体盛+黄连组相反，脾脏指数、肾脏指数升高（P＜0.05）；体虚/体盛+药对组小鼠在高温区的停留比例增加，各生化指标的活性或者含量降低，其中总抗氧化能力显著降低（P＜0.05）。结论：肉桂之“热”不抵黄连之“寒”，黄连-肉桂药对总体表现出寒凉之性。 |
| ABSTRACT： | OBJECTIVE： To explore the transform of the medicinal properties of Coptis chinensis-Cinnamomum cassia couplet medicines before and after mixing. METHODS： Mice were randomly divided into normal group， weak constitution （induced by food restriction and swimming） group， weak constitution+C. chinensis group， weak constitution+C. cassia group， weak constitution+couplet medicine group， prosperous constitution （induced by high protein diet） group， prosperous constitution+C. chinensis group， prosperous constitution+C. cassia group and prosperous constitution+couplet medicine group， with 10 mice in each group. After modeling， each group was given relevant medicine intragastrically by 20 g （crude drug）/（kg·d）， and normal group was given equivalent volume of normal saline intragastrically for consecutive 7 days. The proportion of rats remained in high-temperature areas was recorded. Organ index， biochemical index （Na+/K+-ATPase， Ca2+/Mg2+-ATPase）， total antioxidant capacity （T-AOC）， SOD activity， the serum content of noradrenalin and dopamine were detected. RESULTS： Compared with normal group， proportion of mice in high-temperature area increased in weak constitution group， while liver index， spleen index， renal index， biochemical index activity or content decreased （P＜0.05）； the change of above index in prosperous constitution group were opposite to weak constitution group； above index had statistical significance except for the proportion of mice in high-temperature area （P＜0.05）. Compared with weak constitution/prosperous constitution group， the proportion of mice remained in high-temperature area and liver index increased in weak constitution/prosperous constitution+C. chinensis group， while biochemical index activity or content decreased （P＜0.05）； the change of above index in weak constitution/prosperous constitution+C. cassia group were opposite to C. chinensis group， spleen index and renal index increased （P＜0.05）； the proportion of rats remained in high-temperature area increased in weak constitution/prosperous constitution couplet medicine group， and biochemical index activity or content decreased， among which total antioxidant activity decreased significantly （P＜0.05）. CONCLUSIONS： The couplet medicine manifests the “cold nature” after C. chinensis and C. cassia equally paired， because “hot nature” degree of C. cassia is lower than “cold nature” of C. chinensis. |
| 期刊： | 2016年第27卷第7期 |
| 作者： | 关宇曈，张振秋 |
| AUTHORS： | GUAN Yutong，ZHANG Zhenqiu |
| 关键字： | 黄连；肉桂；黄连-肉桂药对；配伍；冷热板示差法；中药药性；小鼠 |
| KEYWORDS： | Coptis chinensis； Cinnamomum cassia； Coptis chinensis-Cinnamomum cassia couplet medicine； Compatibility； Cold/hot plate differentiating technology； Medicinal property； Mice |
| 阅读数： | 400 次 |
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