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骨肽片联合仙灵骨葆胶囊对经伤椎置钉结合植骨治疗骨质疏松性胸腰椎骨折术后恢复效果的影响
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| 篇名： | 骨肽片联合仙灵骨葆胶囊对经伤椎置钉结合植骨治疗骨质疏松性胸腰椎骨折术后恢复效果的影响 |
| TITLE： | |
| 摘要： | 目的：探讨骨肽片联合仙灵骨葆胶囊对经伤椎置钉结合植骨手术治疗骨质疏松性胸腰椎骨折术后恢复效果的影响。方法：将122例行伤椎置钉结合植骨手术的骨质疏松性胸腰椎骨折患者随机均分为对照组和观察组。两组患者均实施伤椎置钉和植骨治疗。对照组患者给予骨肽片0.3～0.6 g，每日3次，饭后口服；观察组患者在对照组治疗的基础上给予仙灵骨葆胶囊1.5 g，每日2次，饭后口服。两组患者均于手术当天开始服药，4周为1个疗程，两组患者均治疗4个疗程，并于治疗3、6个月后观察治疗前后的疼痛评分、骨密度（BMD）水平和骨钙素（BGP）、骨源性碱性磷酸酶（BALP）、I型前胶原氨基端前肽（PINP）水平变化，同时记录两组患者的临床疗效、胸腰椎再骨折率和不良反应发生率。结果：治疗后，观察组患者总有效率显著高于对照组，两组患者疼痛评分均显著低于治疗前，且随时间延长逐渐降低，观察组低于对照组；两组患者BMD、BGP、BALP和PINP水平均显著高于治疗前，且随时间延长逐渐升高，观察组高于对照组；治疗6个月后，对照患者BGP、BALP和PINP水平均显著高于治疗前，差异均有统计学意义（P＜0.05）。两组患者不良反应、胸腰椎再骨折发生率比较，差异均无统计学意义（P＞0.05）。结论：骨肽片联合仙灵骨葆胶囊可显著改善患者的骨代谢生化指标，促进骨密度提升和骨折断端愈合，且短期用药安全性较好。 |
| ABSTRACT： | OBJECTIVE：To investigate the effects of Ossotide tabletcombined with Xianling gubao capsule on the postoperative recovery effect oftrans-traumatic-verterbrae screw-setting combined with bone grafting in the treatment of osteoporotic thoracolumbar vertebral fractures. METHODS： 122 patients with osteoporotic thoracolumbar vertebral fractures who were treated with trans-traumatic-verterbrae screw-setting combined with bone grafting were randomly divided into control group and observation group.The two groups were treated by trans-traumatic-verterbrae screw-setting with bone grafting.Based on this， the control group was treated with 0.3-0.6 g Ossotide tablet， three times a day， taken orally after meals； observation group was additionally treated with 1.5 g Xianling gubao capsule， twice a day， taken orally after meals. Both of the two groups took medicine on the day of operation. A course induded 4 weeks，and it lasted 4 courses. The indexes were observed after 3 and 6 months treatment. The changes of pain score， bone mineral density （BMD） levels， bone gla protein （BGP）， bone alkali phsphatase （BALP）， procollagen I nterminal peptide （PINP） and other bone metabolism biochemical indexes in 2 groups before and after treatment were observed.Meanwhile，the clinical efficacy， rates of thoracolumbar vertebral refractures and incidence of adverse reactions in the 2 groups were recorded.RESULTS：After treatment， the total effective rate in observation group was significantly higher than control group， pain scores in 2 groups were significantly lower than before， and general decreased by time， observation group was lower than control group； BMD， BGP， BALP and PINP levels in 2 groups were significantly higher than before， and general increased by time， observation group was higher than control group； after 6 months， BMD， BALP and PINP levels in control group were significantly higher than before， the differences were statistically significant（P＜0.05）； there were no significant differences in the incidence of adverse reactions， rates of thoracolumbar vertebral refractures between 2 groups（P＞0.05）. CONCLUSIONS： Ossotide tablet combined with Xianling gubao capsule can significantly improve the bone metabolism biochemical indexes of patients， promote bone mineral density and fracture healing， with good safety in short-term medication. |
| 期刊： | 2016年第27卷第6期 |
| 作者： | 董君博 |
| AUTHORS： | DONG Junbo |
| 关键字： | 骨肽片；仙灵骨葆胶囊；骨质疏松性胸腰椎骨折；恢复效果 |
| KEYWORDS： | Ossotide tablet； Xianling gubao capsule； Osteoporotic thoracolumbar fracture； Recovery effect |
| 阅读数： | 505 次 |
| 本月下载数： | 1 次 |
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