1例肾病综合征合并肺孢子菌肺炎患者的药学监护
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篇名: 1例肾病综合征合并肺孢子菌肺炎患者的药学监护
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摘要: 目的:探讨临床药师在肾病综合征合并肺孢子菌肺炎(PCP)药物治疗中提供药学监护的方法和作用。方法:临床药师参与1例肾病综合征合并PCP患者的药物治疗,从抗感染治疗方案的制订、糖皮质激素用药的优化、用药过程的监护、患者用药教育等方面实施药学监护。同时建议将阿奇霉素0.5 g,ivgtt,qd+复方磺胺甲噁唑片2片,po,q12 h抗感染这一疗效不佳的初始方案,调整为复方磺胺甲噁唑片3片,po,q6 h +克林霉素0.6 g,ivgtt,q8 h,后加用卡泊芬净50 mg,ivgtt,qd;并根据患者疾病进展4次调整注射用甲泼尼龙琥珀酸钠剂量。结果:医师采纳临床药师建议,治疗30 d后患者肺内病灶基本吸收,感染得到控制。结论:临床药师参与抗感染治疗及药学监护,协助医师制订用药方案,促进了临床合理用药,提高了药物临床治疗的有效性和安全性。
ABSTRACT: OBJECTIVE: To explore the method and role of clinical pharmacists in pharmaceutical care for nephrotic syndrome complicated with Pneumocystis carinii pneumonia (PCP). METHODS: Clinical pharmacists participated in the treatment for a patient with nephrotic syndrome complicated with PCP, and implemented pharmaceutical care in terms of the development of anti-infective therapy regimens, glucocorticoid optimization, guardianship for drug use, the medication education for patients. Clinical pharmacists provided suggestion that primary anti-infective plan of azithromycin 0.5 g,ivgtt,qd+Compound sulfalene tablet 2 tablets, po, q12 h; which was not effective,was adjusted plan as Compound sulfalene tablet 3 tablets, po, q6 h+clindamycin 0.6 g, ivgtt, q8 h+caspofungin 50 mg, ivgtt, qd. The dose of Methylprednisolone for injection was adjusted 4 times according to disease progression. RESULTS: Physicians adopted the suggestions of clinical pharmacists. After 30 days of treatment,  lung abnormal lesion was absorbed basically and infection control was achieved. CONCLUSIONS: Clinical pharmacists participate in anti-infective treatment and pharmaceutical care, and assist physicians to develop therapy plan to promote rational drug use in the clinic and improve the effectiveness and safety of clinical treatment.
期刊: 2016年第27卷第5期
作者: 张文竹,李文杰,孙福生,赵艳
AUTHORS: ZHANG Wenzhu,LI Wenjie,SUN Fusheng,ZHAO Yan
关键字: 肾病综合征;肺孢子菌肺炎;临床药师;药学监护
KEYWORDS: Nephrotic syndrome; Pneumocystis carinii pneumonia; Clinical pharmacists; Pharmaceutical care
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