伊立替康单药与联合消癌平治疗老年晚期胃癌的比较研究
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篇名: 伊立替康单药与联合消癌平治疗老年晚期胃癌的比较研究
TITLE:
摘要: 目的:评价伊立替康单药与联合消癌平注射液治疗老年晚期胃癌的疗效及安全性。方法:回顾性收集2012-2014年我院收治的老年晚期胃癌患者60例,按治疗方案的不同分为联合组和单药组,各30例。单药组患者采用伊立替康(CPT-11)150 mg/m2加入250 ml 0.9%氯化钠注射液,ivgtt,联合组患者在单药组基础上加用消癌平注射液80 ml,qd。两组患者均14 d为1个周期,连续治疗4个周期。比较两组患者肿瘤标志物水平、疾病控制率、无进展生存期(PFS)及不良反应发生率。结果:治疗后,两组患者肿瘤标志物血清癌胚抗原、糖类抗原199、糖类抗原242水平显著低于治疗前,且联合组明显低于单药组,差异有统计学意义(P<0.05);联合组患者疾病控制率为70.00%,显著高于单药组的33.33%,联合组患者PFS为(11.23±2.17)个月,显著长于单药组的(9.36±0.84)个月,差异均有统计学意义(P<0.05);联合组患者白细胞减少、丙氨酸转氨酶升高、腹泻、口腔黏膜炎及手足综合征的不良反应发生率显著低于单药组,差异有统计学意义(P<0.05)。结论:消癌平注射液联合伊立替康治疗老年晚期胃癌效果明显,不良反应发生率低。
ABSTRACT: OBJECTIVE: To evaluate therapeutic efficacy and safety of chemotherapy combined with Xiaoaiping injection in the treatment of elderly patients with advanced gastric cancer. METHODS: 60 elderly patients with advanced gastric cancer were collected from our department during 2012-2014, and then divided into union group and single group with 30 cases in each group. Single group was given irinotecan (CPT-11) 150 mg/m2 added into 0.9% Sodium Chloride injection, and union group was additionally given Xiaoaiping injection 80 ml, qd, on the basis of single group. A treatment course lasted for 14 days, and both groups received 4 courses of treatment. The tumor markers, disease single rate, progression-free survival (PFS) and the incidence of ADR were compared between 2 groups. RESULTS: After treatment, the levels of CEA, CA199 and CA242 in 2 groups were significantly lower than before; the union group was significantly lower than the single group, with statistical significance (P<0.05). The disease single rate of union group was 70.00%, which was significantly higher than that of single group (33.33%). PFS of union group was (11.23±2.17) months, which was significantly longer that of single group [(9.36±0.84) months], with statistical significance (P<0.05). The incidence of leucopenia, alanine aminotransferase elevation, diarrhea, stomatitis and hand-foot syndrome in union group was significantly lower than in single group, with statistical significance (P<0.05). CONCLUSIONS: Xiaoaiping injection combined with irinotecan chemotherapy for advanced gastric cancer has obvious effect with a low incidence of ADR.
期刊: 2016年第27卷第5期
作者: 武阳
AUTHORS: WU Yang
关键字: 癌平注射液;伊立替康;晚期胃癌;化疗;疗效;安全性
KEYWORDS: Xiaoaiping injection; Irinotecan; Advanced gastric cancer; Chemotherapy; Efficacy; Safety
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