血必净注射液对脓毒症患者凝血功能及预后的影响
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篇名: 血必净注射液对脓毒症患者凝血功能及预后的影响
TITLE:
摘要: 目的:探讨血必净注射液对脓毒症患者凝血功能及预后的影响。方法:50例脓毒症患者根据入院先后顺序分为对照组与观察组,各25例。对照组患者予常规治疗,观察组患者在常规治疗基础上联合血必净注射液(50 ml,加入5%葡萄糖注射液或0.9%氯化钠注射液250 ml中静脉滴注,bid)治疗,疗程均为7 d。比较两组患者治疗7 d后的凝血功能指标水平、急性生理与慢性健康表(APACHEⅡ)评分及28 d后的病死率。结果:两组患者治疗7 d后的凝血功能各指标较治疗前均明显改善,APACHEⅡ评分较治疗前均明显下降,且观察组改善或下降程度均明显优于对照组,差异有统计学意义(P<0.05);随访28 d,观察组患者的病死率为16%,低于对照组(28%),但差异无统计学意义(P>0.05)。结论:血必净注射液可通过抑制凝血活化、纠正凝血功能紊乱而改善脓毒症病情的严重程度。
ABSTRACT: OBJECTIVE: To investigate the effect of Xuebijing injection on coagulation function and prognosis in patients with sepsis. METHODS: 50 patients with sepsis were randomly divided into control group and observation group according to the hospitalization sequence, with 25 cases in each group. Control group received conventional treatment, and observation group was additionally given Xuebijing injection (50 ml added into 5% Glucose solution or 0.9% Sodium chloride solution 250 ml intravenously, bid) on the basis of conventional treatment. Treatment course lasted for 7 d. The coagulation function, APACHE Ⅱ score after 7 days of treatment and 28 d mortality were compared between 2 groups. RESULTS: After 7 d treatment, the coagulation indexes were improved significantly in 2 groups compared with before treatment, and the APACHEⅡscores were decreased significantly in both groups; the observation group were significantly better than the control group, with statistical significance (P<0.05). After followed up for 28 d, the mortality rate of 2 groups were 16% and 28%, there was no statistical significance (P>0.05). CONCLUSIONS: Xuebijing injection can inhibit blood clotting activation, correct the coagulation disorders, and improve the sepsis severity.
期刊: 2016年第27卷第5期
作者: 林秀娟,唐纪文,钟丽红,程小明
AUTHORS: LIN Xiujuan,TANG Jiwen,ZHONG Lihong,CHENG Xiaoming
关键字: 血必净注射液;脓毒症;凝血功能;预后
KEYWORDS: Xuebijing injection; Sepsis; Coagulation function; Prognosis
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