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尤瑞克林治疗急性分水岭脑梗死患者的疗效观察
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| 篇名： | 尤瑞克林治疗急性分水岭脑梗死患者的疗效观察 |
| TITLE： | |
| 摘要： | 目的：观察尤瑞克林治疗急性分水岭脑梗死（WSI）的临床疗效。方法：将128例急性（WSI）患者，按随机数字表法分为对照组和治疗组，各64例。对照组患者给予舒血宁注射液15 ml加入0.9％氯化钠注射液250 ml，ivgtt，qd；治疗组患者采用注射用尤瑞克林0.15 PNA单位加入0.9％氯化钠注射液100 ml，ivgtt，qd，两组患者均连续治疗14 d。观察两组患者治疗前及治疗后3、7、14 d神经功能缺损评分和临床疗效，并取两组患者治疗后7、14 d血液标本，测定血清补体末端复合体（TCC）水平。结果：治疗后，治疗组患者神经功能缺损评分及总有效率均显著高于对照组，差异有统计学意义（P＜0.01）；治疗前，两组患者TCC水平比较，差异无统计学意义（P＞0.05），治疗后7 d，两组患者TCC水平均显著升高，至14 d时，又有所下降，且治疗组低于对照组，差异有统计学意义（P＜0.05）。结论：尤瑞克林能明显提高急性WSI患者临床疗效，改善患者神经功能缺损症状及TCC水平。 |
| ABSTRACT： | OBJECTIVE： To observe clinical efficacy of urinary kallidinogenase in the treatment of acute cerebral watershed infarct （WSI）. METHODS： 128 patients with WSI were randomly divided into control group and treatment group， each of the 64 cases. Control group was given Shuxuening 15 ml added into 0.9％ Sodium chloride 250 ml， ivgtt， qd； treatment group received urinary kallidinogenase 0.15 PNA added into 0.9％ Sodium chloride 100 ml， ivgtt， qd. Both groups were treated for consecutive 14 days. Neurologic impairment score （NIHSS） and clinical efficacy were observed in 2 groups before treatment and 3， 7 and 14 days after treatment. The blood specimens were collected after 7 and 14 days treatment， to determine serum levels of TCC. RESULTS： After treatment， NIHSS and total effective rate of treatment group were significantly higher than those of control group， with statistical significance （P＜0.01）. There was no statistical significance in TCC between 2 groups before treatment （P＞0.05）； 7 days after treatment， TCC level of 2 groups increased significantly， to 14 days， and a declive； the treatment group was higher than the control group， with statistical significance （P＜0.05）. CONCLUSIONS： Urinary kallidinogenase can improve clinical efficacy of WSI significantly， and promote neurologic impairment symptom and TCC levels. |
| 期刊： | 2016年第27卷第5期 |
| 作者： | 王彬，刘洋，李小圆，王靖，张凤云3，马福莲，刘淑芹 |
| AUTHORS： | WANG Bin，LIU Yang，LI Xiaoyuan，WANG Jing，ZHANG Fengyun，MA Fulian，LIU Shuqin |
| 关键字： | 尤瑞克林；分水岭脑梗死；神经功能缺损评分；血清补体 |
| KEYWORDS： | Urinary kallidinogenase； Cerebral watershed infarct； Neurologic impairment score； Serum complement |
| 阅读数： | 222 次 |
| 本月下载数： | 2 次 |
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