尤瑞克林治疗急性分水岭脑梗死患者的疗效观察
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篇名: 尤瑞克林治疗急性分水岭脑梗死患者的疗效观察
TITLE:
摘要: 目的:观察尤瑞克林治疗急性分水岭脑梗死(WSI)的临床疗效。方法:将128例急性(WSI)患者,按随机数字表法分为对照组和治疗组,各64例。对照组患者给予舒血宁注射液15 ml加入0.9%氯化钠注射液250 ml,ivgtt,qd;治疗组患者采用注射用尤瑞克林0.15 PNA单位加入0.9%氯化钠注射液100 ml,ivgtt,qd,两组患者均连续治疗14 d。观察两组患者治疗前及治疗后3、7、14 d神经功能缺损评分和临床疗效,并取两组患者治疗后7、14 d血液标本,测定血清补体末端复合体(TCC)水平。结果:治疗后,治疗组患者神经功能缺损评分及总有效率均显著高于对照组,差异有统计学意义(P<0.01);治疗前,两组患者TCC水平比较,差异无统计学意义(P>0.05),治疗后7 d,两组患者TCC水平均显著升高,至14 d时,又有所下降,且治疗组低于对照组,差异有统计学意义(P<0.05)。结论:尤瑞克林能明显提高急性WSI患者临床疗效,改善患者神经功能缺损症状及TCC水平。
ABSTRACT: OBJECTIVE: To observe clinical efficacy of urinary kallidinogenase in the treatment of acute cerebral watershed infarct (WSI). METHODS: 128 patients with WSI were randomly divided into control group and treatment group, each of the 64 cases. Control group was given Shuxuening 15 ml added into 0.9% Sodium chloride 250 ml, ivgtt, qd; treatment group received urinary kallidinogenase 0.15 PNA added into 0.9% Sodium chloride 100 ml, ivgtt, qd. Both groups were treated for consecutive 14 days. Neurologic impairment score (NIHSS) and clinical efficacy were observed in 2 groups before treatment and 3, 7 and 14 days after treatment. The blood specimens were collected after 7 and 14 days treatment, to determine serum levels of TCC. RESULTS: After treatment, NIHSS and total effective rate of treatment group were significantly higher than those of control group, with statistical significance (P<0.01). There was no statistical significance in TCC between 2 groups before treatment (P>0.05); 7 days after treatment, TCC level of 2 groups increased significantly, to 14 days, and a declive; the treatment group was higher than the control group, with statistical significance (P<0.05). CONCLUSIONS: Urinary kallidinogenase can improve clinical efficacy of WSI significantly, and promote neurologic impairment symptom and TCC levels.
期刊: 2016年第27卷第5期
作者: 王彬,刘洋,李小圆,王靖,张凤云3,马福莲,刘淑芹
AUTHORS: WANG Bin,LIU Yang,LI Xiaoyuan,WANG Jing,ZHANG Fengyun,MA Fulian,LIU Shuqin
关键字: 尤瑞克林;分水岭脑梗死;神经功能缺损评分;血清补体
KEYWORDS: Urinary kallidinogenase; Cerebral watershed infarct; Neurologic impairment score; Serum complement
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