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多指标综合评分法优选复方双金感冒颗粒的提取工艺
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| 篇名： | 多指标综合评分法优选复方双金感冒颗粒的提取工艺 |
| TITLE： | |
| 摘要： | 目的：优选复方双金感冒颗粒的提取工艺。方法：采用正交试验设计法，以方中金莲花和一枝蒿的有效成分荭草苷、牡荆苷、一枝蒿酮酸的含量和浸膏得率为综合评分指标，考察乙醇体积分数、提取时间、加醇倍量3个因素对乙醇提取效果的影响；以方中神香草等的有效成分总多糖、迷迭香酸的含量和浸膏得率为综合评分指标，考察煎煮次数、煎煮时间、加水倍量3个因素对水提取效果的影响；均进行验证试验。结果：优选的最优醇提工艺为10倍量70％乙醇提取2次，每次1.5 h；最优水提工艺为10倍量水提取3次，每次1 h。验证试验中醇提工艺和水提工艺平均综合评分分别为95.55、97.89（RSD＝1.01％、0.97％，n＝3）。结论：优选的提取工艺简单、稳定、可行，可用于复方双金感冒颗粒的提取。 |
| ABSTRACT： | OBJECTIVE： To optimize the extraction technology of Compound shuangjin ganmao granules. METHODS： The effects of ethanol volume fraction， extraction time and the amount of ethanol on the extraction effect of ethanol were investigated by orthogonal test using the content of effective components of orientoside， vitexin and rupestonic acid in Trollius chinensis and Artemisia rupetris， and the yield of extract as indexes. The effects of decoction times， decoction time and the amount of added water on the extraction effects were investigated using the contents of effective components of total polysaccharide and rosmarinci acid in Hyssopus officinalis， and the yield of extraction as indexes. Validation test was conducted. RESULTS： Optimum ethanol extraction technology conditions were as follows as 10-fold 70％ ethanol， extracting for 2 times， lasting for 1.5 h each time. Optimum water extraction technology conditions were as follows as 10-fold water， extracting for 3 times， lasting for 1 h each time. Results of validation test showed that average comprehensive score of ethanol extraction technology and water extraction technology were 95.55 （RSD＝1.01％， n＝3） and 97.89 （RSD＝0.97％， n＝3）. CONCLUSIONS： Optimized extraction technology is simple， stable and feasible， which can be used for the extraction of Compound shuangjin ganmao granules. |
| 期刊： | 2016年第27卷第4期 |
| 作者： | 刘桂花，何承辉，帕依曼·亥米提，王云飞，邢建国 |
| AUTHORS： | LIU Guihua，HE Chenghui，Payiman·Haimiti，WANG Yunfei，XING Jianguo |
| 关键字： | 复方双金感冒颗粒；工艺优化；醇提；水提；正交试验；综合评分 |
| KEYWORDS： | Compound shuangjin ganmao granules； Technology optimization； Ethanol extraction； Water extraction； Orthogonal test； Comprehensive score |
| 阅读数： | 278 次 |
| 本月下载数： | 2 次 |
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