目的：研究加味麻黄蝉衣汤对变应性鼻炎（AR）模型豚鼠的改善作用及其机制。方法：将32 只豚鼠随机均分为正常

（0.9％氯化钠注射液）组、模型（0.9％氯化钠注射液）组、实验[加味麻黄蝉衣汤，5.18 g（生药）/kg]组和对照[丙酸氟替卡松鼻喷雾

剂，50 μg/（只·d）]组，除正常组外其余各组豚鼠ip 卵清蛋白和氢氧化铝各30 mg复制AR模型。除对照组喷雾给药外，其余各组ig

相应药物，每天2 次，连续15 d。观察豚鼠的鼻部症状并进行评分，免疫组化法检测鼻黏膜酪氨酸磷酸酶1（SHP-1）的蛋白表达水

平，酶联免疫吸附法检测血清中白细胞介素4（IL-4）、干扰素γ（IFN-γ）的含量。结果：与正常组比较，模型组豚鼠出现AR症状，评

分增加，鼻黏膜SHP-1 蛋白表达水平升高，血清中IL-4 含量增加、IFN-γ含量减少（P＜0.05）；与模型组比较，实验组和对照组豚鼠

AR症状改善，评分降低，鼻黏膜SHP-1 蛋白表达水平降低，血清中IL-4 含量减少、IFN-γ含量增加（P＜0.05）。结论：加味麻黄蝉衣

汤对AR有一定的改善作用，其机制可能与减少血清中IL-4 的含量、增加血清中IFN-γ的含量有关。

OBJECTIVE：To study improvement effect of modified mahuang chanyi decoction on allergic rhinitis（AR）model

guinea pigs and its mechanism. METHODS：32 guinea pigs were randomly divided into normal group （0.9％ Sodium chloride injection），

model group（0.9％ Sodium chloride injection），experimental [Modified mahuang chanyi decoction，5.18 g（medicinal

materials）/kg] group and control [Fluticasone propionate nasal spray，50 μg/（guinea pig·d）] group. Except for normal group，other

groups received ovalbumin 30 mg and calmogastrin 30 mg intraperitoneally to induce AR model. Except for control group，other

groups were given relevant medicine intragastrically，twice a day for consecutive 15 d. Nasal symptoms of guinea pigs were observed

and recorded，and then analyzed and scored. The protein expression of nasal mucosa SHP-1 was detected by immunohistochemistry，

the serum contents of IL-4 and IFN-γ were determined by enzyme-linked immunosorbent assay. RESULTS：Compared

with normal group，model group suffered from AR symptom，and nasal symptoms score was increased；and the protein expression

of nasal mucosa SHP-1 and the serum content of IL-4 increased，while the content of IFN-γ decreased（P＜0.05）. Compared with

model group，AR symptom of experimental group and control group were improved；nasal symptoms score，the protein expression

of nasal mucosa SHP-1 and the serum content of IL-4 decreased while the content of IFN-γ increased（P＜0.05）. CONCLUSIONS：

Modified mahuang chanyi decoction shows certain improvement effect on AR，and its mechanism is associated the decrease of IL-4

content and the increase of IFN-γ content in serum.