目的：测定癌痛巴布剂中细辛脂素释放度和离体大鼠透皮率。方法：采用自制的释放度装置以及改良的Franz 扩散池，以

离体的大鼠皮肤为屏障、生理盐水为溶剂，采用高效液相色谱法测定细辛脂素含量，考察癌痛巴布剂20、50、80、120 min 内的释放

度和2、4、8、12、24 h 内的透皮量，计算累计释放度和累计透皮率。结果：癌痛巴布剂中细辛脂素的120 min累计释放度为73.01％；

24 h 离体透皮率为26.01％，细辛酯素的透皮动力学方程为Q＝5.717 7t1/2－0.385 4（r＝0.979）。结论：癌痛巴布剂具有良好的释放

及透皮性能，透皮动力学符合Higuchi方程。

OBJECTIVE：To determinate the release rate and in vitro transdermal rate of asarinin in Cancer pain cataplasm.

METHODS：Using homemade devices and modified France diffusion，isolated skin of rats as barrier，normal saline as solvent，the

content of asarinin was determined by HPLC. Release rate of Cancer pain cataplasm within 20，50，80 and 120 min and transdermal

amount within 2，4，8，12，24 h were investigated，and accumulative release rate and accumulative transdermal rate were calculated.

RESULTS：Accumulative release rate by 120 min of asarinin in Cancer pain cataplasm was 73.01％；24 h in vitro transdermal

rate was 26.01％ ，and transdermal kinetics equation of asarinin was Q＝5.717 7t1/2 － 0.385 4（r＝0.979）. CONCLUSIONS：

Cancer pain cataplasm has good release and transdermal performance. Its transdermal kinetics is in line with Higuchi equation.